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Neutral-cationic lipid for nucleic acid and drug delivery

  • US 6,974,589 B1
  • Filed: 10/10/2000
  • Issued: 12/13/2005
  • Est. Priority Date: 10/08/1999
  • Status: Expired due to Term
First Claim
Patent Images

1. A liposome composition comprising:

  • a lipid having the formula embedded image

    wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms;

    n=0–

    20;

    L is selected from the group consisting of (i) —

    X—

    (C═

    O)—

    Y —

    , (ii) —

    X—

    (C═

    O)—

    , wherein X and Y are independently selected from oxygen, NH, and a direct bond, and (iii) —

    O—

    CH2

    ; and

    Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0.

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