Methods for non-invasive analyte measurement from the conjunctiva
First Claim
1. A method of determining glucose concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising the steps:
- a. exposing at least a portion of the conjunctiva surface of the subject to electromagnetic radiation without contact with the ocular surface;
b. detecting electromagnetic radiation reflected from the conjunctiva without contact with the ocular surface; and
, c. determining a radiation signature of said reflected electromagnetic radiation to determine glucose concentration in the tissue of the subject.
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Abstract
The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject'"'"'s conjunctiva. The spectra of mid-infrared radiation emitted from a subject'"'"'s body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
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Citations
10 Claims
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1. A method of determining glucose concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising the steps:
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a. exposing at least a portion of the conjunctiva surface of the subject to electromagnetic radiation without contact with the ocular surface;
b. detecting electromagnetic radiation reflected from the conjunctiva without contact with the ocular surface; and
,c. determining a radiation signature of said reflected electromagnetic radiation to determine glucose concentration in the tissue of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification