Mass transport limited in vivo analyte sensor
First Claim
1. An electrochemical sensor for subcutaneous glucose sensing, the sensor comprising:
- a body having a top layer impervious to glucose and a base layer impervious to glucose;
a working electrode positioned between the top layer and the base layer;
an analyte-responsive sensing layer comprising glucose oxidase and redox polymer proximate the working electrode; and
an open channel extending through the top layer to at least the working eletrode and the sensing layer, the sensing layer exposed for contact with glucose via the open channel, wherein a sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer.
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Abstract
An in vivo electrochemical sensor including a working electrode, and an analyte-responsive sensing layer proximate the working electrode. The sensing layer is exposed at an edge of the sensor, wherein the sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer. The sensor is configured and arranged for implantation into the body of a mammal for contact with body fluids of the mammal. The analyte diffuses to the sensing element via the edge of the sensor, thereby restricting mass transport of the analyte to the sensing element. This is because the solution-contacting surface area of the sensor edge is much smaller than an open face of the sensing layer.
517 Citations
10 Claims
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1. An electrochemical sensor for subcutaneous glucose sensing, the sensor comprising:
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a body having a top layer impervious to glucose and a base layer impervious to glucose;
a working electrode positioned between the top layer and the base layer;
an analyte-responsive sensing layer comprising glucose oxidase and redox polymer proximate the working electrode; and
an open channel extending through the top layer to at least the working eletrode and the sensing layer, the sensing layer exposed for contact with glucose via the open channel, wherein a sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification