Noninvasive devices, methods, and systems for shrinking of tissues

• US 6,976,492 B2
• Filed: 01/07/2003
• Issued: 12/20/2005
• Est. Priority Date: 08/13/1997
• Status: Expired due to Term

• Current Assignee: Verathon Incorporated (Roper Technologies, Inc.)
• Original Assignee: Solarant Medical, Inc. (Endo International PLC)
• Inventors: Ingle, Frank, Laird, Robert J., Claude, John P., Carter, Garry L., Do, Paul, Mosel, Brian J.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US10/338,193
• Publication Number:
  US 20030139790A1
• Time in Patent Office: 1,078 Days
• Field of Search: 606/41, 606/45, 606 48- 50, 607101-105, 607/138, 128/898
• US Class Current: 128/898
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/1482 having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
• CPC Class Codes: A61B 18/1485 having a short rigid shaft for accessing the inner body through natural openings
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00095 high, i.e. heat conducting
• CPC Class Codes: A61B 2018/00148 with metal
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00232 having an irregular shape
• CPC Class Codes: A61B 2018/00505 Urinary tract
• CPC Class Codes: A61B 2018/00517 Urinary bladder or urethra
• CPC Class Codes: A61B 2018/00523 Treatment of incontinence
• CPC Class Codes: A61B 2018/00553 Sphincter
• CPC Class Codes: A61B 2018/00559 Female reproductive organs
• CPC Class Codes: A61B 2018/00791 : Temperature
• CPC Class Codes: A61B 2018/1253 : monopolar
• CPC Class Codes: A61B 2018/126 : bipolar
• CPC Class Codes: A61B 2018/1273 : including multiple generators in one device
• CPC Class Codes: A61B 2018/1425 : Needle
• CPC Class Codes: A61B 2018/1467 : using more than two electrodes on a single probe
• CPC Class Codes: A61B 2018/1472 : for use with liquid electrolyte, e.g. virtual electrodes
• CPC Class Codes: A61B 2090/3782 : transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 2218/002 : Irrigation
• CPC Class Codes: A61N 1/06 : for high-frequency therapy
• CPC Class Codes: A61N 1/403 : for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 7/02 : Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient'"'"'s own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.

Claims

1. A method for treating urinary incontinence in a patient, the method comprising:

transmitting energy from a probe to a collagenous target tissue comprising or supporting the urethra of a patient, wherein the energy heats the target tissue so as to inhibit incontinence; and

cooling tissue in the vicinity of the probe.

2. The method of claim 1, wherein transmitting energy is carried out by energizing an electrode of the probe.

3. The method of claim 2, wherein the electrode comprises a needleless electrode.

4. The method of claim 2, further comprising advancing the electrode of the probe into tissue, the electrode comprising a needle electrode.

5. The method of claim 1, wherein the energy comprises RF energy.

6. The method of claim 1, wherein cooling is carried out before, after, or during heating of the target tissue by the probe.

7. The method of claim 1, wherein cooling is carried out by a cooled probe surface.

8. The method of claim 1, wherein cooling is carried out by a cooled electrode.

9. The method of claim 1, wherein cooling is carried out by delivering cooling fluids.

10. The method of claim 9, wherein the fluid comprises chilled saline or water.

11. The method of claim 1, wherein transmitting energy comprises repositioning a bladder or a bladder neck as a therapy for urinary incontinence.

12. The method of claim 1, further comprising introducing the probe transvaginally.

13. A method for treating urinary incontinence in a patient, the method comprising:

directing energy from a probe, through an intermediate tissue, and into a target tissue, wherein the energy heats the target tissue so as to inhibit incontinence; and

cooling the intermediate tissue with the probe.

14. The method of claim 13, wherein directing energy is carried out by energizing an electrode of the probe.

15. The method of claim 14, wherein the electrode comprises a needleless electrode.

16. The method of claim 14, further comprising advancing the electrode of the probe into tissue, the electrode comprising a needle electrode.

17. The method of claim 13, wherein the energy comprises RF energy.

18. The method of claim 13, wherein cooling is carried out before, after, or during heating of the target tissue by the probe.

19. The method of claim 13, wherein cooling is carried out by a cooled probe surface.

20. The method of claim 13, wherein cooling is carried out by a cooled electrode.

21. The method of claim 13, wherein cooling is carried out by delivering cooling fluids.

22. The method of claim 21, wherein the fluid comprises chilled saline or water.

23. The method of claim 13, wherein directing energy comprises repositioning a bladder or a bladder neck as a therapy for urinary incontinence.

24. The method of claim 13, further comprising introducing the probe transvaginally, the target tissue comprising endopelvic fascia and the intermediate tissue comprising a vaginal wall.