Method of inducing a CTL response
First Claim
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1. A method of inducing a CTL response in a mammal, which method comprises:
- delivering a liquid comprising an antigen directly to a lymph node or lymph vessel of the mammal at a level sufficient to induce an antigen-specific CTL response in the mammal; and
maintaining the antigen in the mammal'"'"'s lymphatic system over time sufficient to induce the CTL response.
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Abstract
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal'"'"'s lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
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Citations
32 Claims
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1. A method of inducing a CTL response in a mammal, which method comprises:
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delivering a liquid comprising an antigen directly to a lymph node or lymph vessel of the mammal at a level sufficient to induce an antigen-specific CTL response in the mammal; and
maintaining the antigen in the mammal'"'"'s lymphatic system over time sufficient to induce the CTL response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 15, 17, 18, 19, 20, 21, 22, 29, 30)
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8. A method of inducing a CTL response in a mammal, which method comprises:
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delivering a liquid comprising an antigen in a continuous, repeated, or sustained manner directly to a lymph node or lymph vessel of the mammal at a level sufficient to induce an antigen-specific CTL response in the mammal; and
maintaining the antigen in the mammal'"'"'s lymphatic system over time sufficient to induce the CTL response. - View Dependent Claims (9, 10, 11, 12, 13, 14, 16, 23, 24, 25, 26, 27, 28, 31, 32)
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Specification