Oligodeoxynucleotide and its use to induce an immune response
First Claim
1. A substantially pure or isolated oligodeoxynucleotide of between 18 and 30 nucleotides in length, comprising any one of5′
(SEQ ID NO;
;
12)
5′
-X1X2TGCACCGGTGCAGGGGGG-3′
;
(SEQ ID NO;
13)
5′
-X1X2TGCGTCGACGCAGGGGGG-3′
;
(SEQ ID NO;
15)
5′
-X1X2TGCGCCGGCGCAGGGGGG-3′
;
(SEQ ID NO;
17)
5′
-GGTGCATCGATGCAGGGGGG-3′
;
(SEQ ID NO;
1)
5′
-GGTGCGTCGACGCAGGGGGG-3′
;
(SEQ ID NO;
31)
5′
-GGTGCACCGGTGCAGGGGGG-3′
;
or(SEQ ID NO;
2)
5′
-GGTGCATCGATGCAGGGGG-3′
;
(SEQ ID NO;
73).
5 Assignments
0 Petitions
Accused Products
Abstract
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula:
5′X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6(W)M(G)N-3′
wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
236 Citations
13 Claims
- 1. A substantially pure or isolated oligodeoxynucleotide of between 18 and 30 nucleotides in length, comprising any one of
5′ - -X1X2TGCATCGATGCAGGGGGG-3′
;
(SEQ ID NO;
12)5′
-X1X2TGCACCGGTGCAGGGGGG-3′
;(SEQ ID NO;
13)5′
-X1X2TGCGTCGACGCAGGGGGG-3′
;(SEQ ID NO;
15)5′
-X1X2TGCGCCGGCGCAGGGGGG-3′
;(SEQ ID NO;
17)5′
-GGTGCATCGATGCAGGGGGG-3′
;(SEQ ID NO;
1)5′
-GGTGCGTCGACGCAGGGGGG-3′
;(SEQ ID NO;
31)5′
-GGTGCACCGGTGCAGGGGGG-3′
;
or(SEQ ID NO;
2)
5′
-GGTGCATCGATGCAGGGGG-3′
;(SEQ ID NO;
73).- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- -X1X2TGCATCGATGCAGGGGGG-3′
Specification