Assay plates, reader systems and methods for luminescence test measurements
First Claim
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1. An apparatus for measuring electrode induced luminescence from a multi-well assay plate having a plurality of wells comprising one or more electrodes within said wells, said apparatus comprising:
- (a) an electrical energy source;
(b) a plate support;
(c) electrical connections connected to said electrical energy source for electrically connecting said electrodes to said electrical energy source; and
(d) a light detector positioned in a movable relationship relative to said support, wherein said apparatus is configured to;
(i) sequentially align said light detector with each of a plurality of sections of said multi-well plate held in said support, each section comprising one or more wells of said plate; and
(ii) sequentially measure, from an aligned section of said plate, electrode induced luminescence from the wells in said aligned section.
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Abstract
Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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Citations
60 Claims
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1. An apparatus for measuring electrode induced luminescence from a multi-well assay plate having a plurality of wells comprising one or more electrodes within said wells, said apparatus comprising:
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(a) an electrical energy source;
(b) a plate support;
(c) electrical connections connected to said electrical energy source for electrically connecting said electrodes to said electrical energy source; and
(d) a light detector positioned in a movable relationship relative to said support, wherein said apparatus is configured to;
(i) sequentially align said light detector with each of a plurality of sections of said multi-well plate held in said support, each section comprising one or more wells of said plate; and
(ii) sequentially measure, from an aligned section of said plate, electrode induced luminescence from the wells in said aligned section. - View Dependent Claims (5, 6, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38, 47, 48, 49, 50, 52, 53, 54, 55)
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2. An apparatus for measuring electrode induced luminescence from a multi-well assay plate having a plurality of wells comprising one or more electrodes within said wells, said apparatus comprising:
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(a) an electrical energy source;
(b) a plate support;
(c) electrical connections connected to said electrical energy source, said connections configured in a movable relationship relative to said plate support and said apparatus being configured to;
(i) move the electrical connections relative to said plate support so that the electrical connections sequentially connect said electrical energy source to each of a plurality of sections of a multi-well plate held in said support, each section comprising one or more wells of said plate; and
(ii) simultaneously apply electrical energy to electrodes in said wells of a section when that section is held in contact with the electrical connections; and
(d) a light detector positioned to measure electrode induced luminescence from the wells of said section in contact with said electrical connections. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 16, 37, 46, 51)
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3. A method for measuring electrode induced luminescence from a multi-well assay plate having a plurality of wells comprising one or more electrodes within said wells, said method comprising:
(a) simultaneously providing electrical energy to the electrodes in the wells of a first section of said multi-well plate, said section comprising at least two wells, and measuring electrode induced luminescence generated in the wells of said section; and
(b) simultaneously providing electrical energy to the electrodes in the wells of a second section of said multi-well plate, said second section comprising at least two wells not in said first section, and measuring electrode induced luminescence generated in the wells of said second section.- View Dependent Claims (39, 41, 42, 43, 44, 45)
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4. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
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(a) forming an image of luminescence generated in a first section of said multi-well assay plate with a camera, said first section comprising at least two wells; and
(b) forming an image of luminescence generated in a second section of said multi-well assay plate, said second section comprising at least two wells not in said first section. - View Dependent Claims (40)
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56. A method for measuring electrode induced luminescence from a multi-well assay plate having a plurality of wells comprising electrodes, said method comprising:
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(a) simultaneously providing electrical energy to a first electrode in a first well of said multi-well plate and a first electrode in a second well of said multi-well plate, and measuring electrode induced luminescence generated at said first electrodes in said first and second wells; and
(b) simultaneously providing electrical energy to a second electrode in said first well and a second electrode in said second well and measuring electrode induced luminescence generated at said second electrodes in said first and second wells. - View Dependent Claims (57, 58, 59, 60)
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Specification