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Method for in vivo delivery of therapeutic agents

  • US 6,978,172 B2
  • Filed: 12/30/2002
  • Issued: 12/20/2005
  • Est. Priority Date: 11/05/1997
  • Status: Expired due to Fees
First Claim
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1. A method of in vivo administration of a therapeutic agent including the following steps:

  • (a) contacting a device which includes an agent permeable membrane having a pair of contact electrodes to a site of administration such that the agent permeable membrane directly contacts the site of administration, a casing attached to the agent permeable membrane forming a reservoir, a pharmaceutical composition including the therapeutic agent where the pharmaceutical composition is contained in the reservoir, an iontophoretic electrode which is located in the reservoir;

    (b) contacting a counter electrode to a second site;

    (c) applying a first electric signal to the contact electrodes; and

    (d) applying a second electric signal to the iontophoretic electrode.

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