Differentiating acute myocardial infarction from other ECG abnormalities
First Claim
1. A method for clarifying a subject'"'"'s collected ECG waveform for analysis by first effectively removing a recognized, embedded influence over certain characteristics of that waveform which exists by virtue of the physiologic presence, in the subject'"'"'s heart, of a particular ECG confounder, said method comprisingcreating a reference ECG waveform model which possesses the characteristics of an ECG waveform that is influenced by the presence of the particular confounder,linking the model to an ECG purge algorithm which, in cooperation with the model, can be applied to such a subject'"'"'s collected ECG waveform to remove the influence of the confounder, andapplying the linked model and purge algorithm to such a collected ECG waveform, thus to produce a purge-processed ECG waveform that lacks the influence of the selected confounder,wherein said creating comprises quantitative modeling of ST abnormalities due to the presence of Left Bundle Branch Block (LBBB) within the traditional 12-lead resting ECG, and said modeling includes (a) identifying ECG leads for which LBBB induced ST deviation (modST) will be estimated, (b) for each such lead being considered, measuring the largest positive and the largest negative voltage deflections (PosMax, NegMax), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated LBBB induced deviation:
- (estST);
estST=−
(NegMax-STdev)+(PosMas−
STdev)/10, and (e) establishing, lead-by-lead, the direct current (DC) offset constant value component for use in a normalizing equation.
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Abstract
A method for differentiating acute myocardial infarction (AMI) from other ECG abnormalities. The method is performed by modeling selected ECG confounders that tend to obscure AMI evidence in the ECG waveform, and by purging a subject'"'"'s ECG waveform of the effect(s) of these confounders through linking selected confounder models with an appropriate, computer-implementable purge algorithm.
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Citations
4 Claims
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1. A method for clarifying a subject'"'"'s collected ECG waveform for analysis by first effectively removing a recognized, embedded influence over certain characteristics of that waveform which exists by virtue of the physiologic presence, in the subject'"'"'s heart, of a particular ECG confounder, said method comprising
creating a reference ECG waveform model which possesses the characteristics of an ECG waveform that is influenced by the presence of the particular confounder, linking the model to an ECG purge algorithm which, in cooperation with the model, can be applied to such a subject'"'"'s collected ECG waveform to remove the influence of the confounder, and applying the linked model and purge algorithm to such a collected ECG waveform, thus to produce a purge-processed ECG waveform that lacks the influence of the selected confounder, wherein said creating comprises quantitative modeling of ST abnormalities due to the presence of Left Bundle Branch Block (LBBB) within the traditional 12-lead resting ECG, and said modeling includes (a) identifying ECG leads for which LBBB induced ST deviation (modST) will be estimated, (b) for each such lead being considered, measuring the largest positive and the largest negative voltage deflections (PosMax, NegMax), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated LBBB induced deviation: - (estST);
estST=−
(NegMax-STdev)+(PosMas−
STdev)/10, and (e) establishing, lead-by-lead, the direct current (DC) offset constant value component for use in a normalizing equation.
- (estST);
-
2. A method for clarifying a subject'"'"'s collected ECG waveform for analysis by first effectively removing a recognized, embedded influence over certain characteristics of that waveform which exists by virtue of the physiologic presence, in the subject'"'"'s heart, of a particular ECG confounder, said method comprising
creating a reference ECG waveform model which possesses the characteristics of an ECG waveform that is influenced by the presence of the particular confounder, linking the model to an ECG purge algorithm which, in cooperation with the model, can be applied to such a subject'"'"'s collected ECG waveform to remove the influence of the confounder, and applying the linked model and purge algorithm to such a collected ECG waveform, thus to produce a purge-processed ECG waveform that lacks the influence of the selected confounder, wherein said creating comprises to quantitative modeling of ST abnormalities due to the presence of Right Bundle Branch Block (RBBB) within the traditional 12-lead resting ECG, and said modeling includes (a) identifying ECG leads for which RBBB induced ST deviation (modST) will be estimated, (b) for each such lead being considered, measuring the positive and negative magnitudes of the voltage deflection at the point ⅔ - after the QRS onset (TermMax, TermMin), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated RBBB induced deviation (estST);
estST=−
(TermMin−
STdev)+(TermMax−
STdev)/10, and (e) establishing, lead-by-lead, the direct current (DC) offset constant value component for use in a normalizing equation.
- after the QRS onset (TermMax, TermMin), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated RBBB induced deviation (estST);
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3. A method for clarifying a subject'"'"'s collected ECG waveform for analysis by first effectively removing a recognized, embedded influence over certain characteristics of that waveform which exists by virtue of the physiologic presence, in the subject'"'"'s heart, of a particular ECG confounder, said method comprising
creating a reference ECG waveform model which possesses the characteristics of an ECG waveform that is influenced by the presence of the particular confounder, linking the model to an ECG purge algorithm which, in cooperation with the model, can be applied to such a subject'"'"'s collected ECG waveform to remove the influence of the confounder, and applying the linked model and purge algorithm to such a collected ECG waveform, thus to produce a purge-processed ECG waveform that lacks the influence of the selected confounder, wherein said creating comprises quantitative modeling of ST abnormalities due to the presence of Left Ventricular Hypertrophy within the traditional 12-lead resting ECG, and said modeling includes (a) identifying ECG leads for which LVH induced ST deviation (modST) will be estimated, (b) for the frontal leads (I, III, III, − - aVR, aVL, aVF), measuring the largest positive and largest negative voltage deflections (PosMax, NegMax), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated frontal lead LVH induced deviation (estST);
estST=−
(NegMax−
STdev)+(PosMax−
STdev)/40, (e) establishing the estimated precordial lead LVH induced deviation, and (f) establishing, lead-by-lead, the direct current (DC) offset constant value component for use in a normalizing equation.
- aVR, aVL, aVF), measuring the largest positive and largest negative voltage deflections (PosMax, NegMax), (c) calculating the actual ST deviation (STdev) at the J+20 ms point, (d) calculating the estimated frontal lead LVH induced deviation (estST);
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4. A method for clarifying a subject'"'"'s collected ECG waveform for analysis by first effectively removing a recognized, embedded influence over certain characteristics of that waveform which exists by virtue of the physiologic presence, in the subject'"'"'s heart, of a particular ECG confounder, said method comprising
creating a reference ECG waveform model which possesses the characteristics of an ECG waveform that is influenced by the presence of the particular confounder, linking the model to an ECG purge algorithm which, in cooperation with the model, can be applied to such a subject'"'"'s collected ECG waveform to remove the influence of the confounder, and applying the linked model and purge algorithm to such a collected ECG waveform, thus to produce a purge-processed ECG waveform that lacks the influence of the selected confounder, wherein said creating comprises quantitative modeling of ST abnormalities due to the presence of Left Ventricular Hypertrophy with STT abnormalities within a traditional 12-lead resting ECG, and said modeling includes (a) for each such lead being considered, measuring the largest positive and largest negative voltage deflections (PosMax, NegMax), (b) calculating the actual ST deviation (STdev) at the J+20 ms point, (c) for frontal leads, and for selected precordial leads calculating the estimated LVH/STT induced deviation (estST): - estST=−
(NegMax−
STdev)+(PosMax−
STdev)/20, (d) for the remaining precodial leads, calculating the estimated LVH/STT induced deviation (estST);
estST=−
(NegMax−
STdev)+(PosMax−
STdev)/40, and (e) establishing, lead-by-lead, the direct current (DC) offset constant value component for use in a normalizing equation.
- estST=−
Specification