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Bioreactor design and process for engineering tissue from cells

  • US 6,979,308 B1
  • Filed: 06/05/2000
  • Issued: 12/27/2005
  • Est. Priority Date: 06/03/1999
  • Status: Expired due to Fees
First Claim
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1. A bioreactor, comprising:

  • (a) a housing having an inner side comprising;

    a gas introduction means integral to the housing; and

    a gas expiration means integral to the housing;

    (b) a plurality of modules of hollow fibers, residing within the housing, each module comprising;

    (i) at least three coaxially arranged hollow fibers, each hollow fiber having an inner side and an outer side, including an innermost hollow fiber and an outermost hollow fiber;

    (ii) at least three compartments, comprising;

    a first compartment defined by an inner side of an innermost hollow fiber and at least two compartments defined by a respective annular space between adjacent fibers of the at least three coaxially arranged hollow fibers; and

    (c) an outermost compartment defined by a space within the inner side of the housing which is not occupied by the plurality of modules;

    in which at least one compartment is charged with a gaseous nutrient substantially free of non-gaseous fluids.

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