Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
First Claim
Patent Images
1. A method for inducing corpus cavernosal relaxation activity, which comprises:
- administering to a mammal in need thereof, a pharmaceutically effective amount of a compound of formula (II) and a pharmaceutically effective carrier,
where R1 is —
CH3 or —
CH2CH(CH3)2, andR2 iswhere R3 and R4 are independently selected from the group consisting of OCH3, CH3, NO2, F, Cl, Br and I,wherein the compound has been synthesized from theophylline (1-methyl, 3-methyl xanthine) or IBMX (1-methyl-3-isobutyl xanthine).
1 Assignment
0 Petitions
Accused Products
Abstract
The invention pertains to theophylline (1-methyl, 3-methyl xanthine) and IBMX (1-methyl, 3-isobutyl xanthine) derivatives of formulas I and II:
where R1 is —CH3 or —CH2CH(CH3)2, and
R2 is
where R3 and R4 are independently selected from the group consisting of OCH3, CH3, NO2, F, Cl, Br and I.
-
Citations
2 Claims
-
1. A method for inducing corpus cavernosal relaxation activity, which comprises:
-
administering to a mammal in need thereof, a pharmaceutically effective amount of a compound of formula (II) and a pharmaceutically effective carrier, where R1 is —
CH3 or —
CH2CH(CH3)2, andR2 is where R3 and R4 are independently selected from the group consisting of OCH3, CH3, NO2, F, Cl, Br and I, wherein the compound has been synthesized from theophylline (1-methyl, 3-methyl xanthine) or IBMX (1-methyl-3-isobutyl xanthine).
-
-
2. A method for inducing corpus cavernosal relaxation activity, which comprises:
-
administering to a mammal in need thereof, a pharmaceutically effective amount of a compound of formula (I) and a pharmaceutically effective carrier, where R1 is —
CH3 or —
CH2CH(CH3)2, andR2 is where R3 and R4 are independently selected from the group consisting of OCH3, CH3, NO2, F, Cl, Br and I, wherein the compound has been synthesized from theophylline (1-methyl, 3-methyl xanthine) or IBMX (1-methyl-3-isobutyl xanthine).
-
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeCho-Jan Liang, Ing-Jun Chen
-
Original AssigneeCho-Jan Liang, Ing-Jun Chen
-
InventorsChen, Ing-Jun
-
Primary Examiner(s)McKenzie, Thomas C.
-
Application NumberUS10/256,115Time in Patent Office1,187 DaysField of Search514/252.16, 514/263.34, 544/267, 544/272US Class Current514/252.16CPC Class CodesC07D 473/06 with radicals containing on...C07D 473/08 with methyl radicals in pos...
