Ocular analyte sensor
First Claim
Patent Images
1. An ophthalmic lens for detecting glucose in an ocular fluid, comprising:
- competitor moieties;
glucose oxidase molecules comprising glucose/competitor moiety binding sites to which glucose and competitor moieties can reversibly bind; and
detectable labels which are associated with the glucose oxidase molecules and/or the competitor moieties and which are capable of generating an optical signal that changes in a concentration-dependent manner when glucose reversibly binds to the glucose/competitor moiety binding sites.
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Abstract
An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
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Citations
25 Claims
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1. An ophthalmic lens for detecting glucose in an ocular fluid, comprising:
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competitor moieties;
glucose oxidase molecules comprising glucose/competitor moiety binding sites to which glucose and competitor moieties can reversibly bind; and
detectable labels which are associated with the glucose oxidase molecules and/or the competitor moieties and which are capable of generating an optical signal that changes in a concentration-dependent manner when glucose reversibly binds to the glucose/competitor moiety binding sites. - View Dependent Claims (2, 3, 4)
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5. A glucose sensor system, comprising:
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an ophthalmic lens for detecting glucose in an ocular fluid, wherein the ophthalmic lens includes competitor moieties, glucose oxidase molecules having glucose/competitor moiety binding sites to which glucose and the competitor moieties can reversibly bind, and detectable labels which are associated with the glucose oxidase molecules and/or the competitor moieties and which are capable of generating an optical signal that changes in a concentration-dependent manner when glucose reversibly binds to the glucose/competitor moiety binding sites; and
a detector configured to detect the optical signal. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A method for measuring glucose concentration in an ocular fluid, comprising the steps of:
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contacting the ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises competitor moieties, glucose oxidase molecules each of which comprises a glucose/competitor moiety binding site to which glucose and competitor moieties can reversibly bind, and one or more detectable labels which are associated with the glucose oxidase molecules and/or the competitor moieties and which are capable of generating an optical signal that changes in a concentration-dependent manner when glucose reversibly binds to the glucose/competitor moiety binding sites; and
detecting the optical signal to determine the concentration of glucose in the ocular fluid. - View Dependent Claims (14, 15, 16, 17, 20)
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18. A method for varying glucose concentration in a body fluid or tissue, comprising the steps of:
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contacting an ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises competitor moieties;
glucose oxidase molecules each of which comprises a glucose/competitor moiety binding site to which glucose and competitor moieties can reversibly bind; and
one or more detectable labels which are associated with the glucose oxidase molecules and/or the competitor moieties and which are capable of generating an optical signal that changes in a concentration-dependent manner when glucose reversibly binds to the glucose/competitor moiety binding sitesdetecting the optical signal to determine the concentration of glucose in the ocular fluid;
transmitting a signal indicating the glucose concentration in the ocular fluid to a pump configured to vary the glucose concentration in the body tissue or fluid; and
providing a regulator moiety via the pump to the body tissue or fluid, whereby the glucose concentration in the body tissue or fluid is varied. - View Dependent Claims (19, 21, 22, 23, 24, 25)
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Specification