Electrostatic loading of drugs on implantable medical devices

• US 6,982,004 B1
• Filed: 11/26/2002
• Issued: 01/03/2006
• Est. Priority Date: 11/26/2002
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Hossainy, Syed F. A., Malik, Shamim
• Primary Examiner(s): Fiorilla, Chris
• Assistant Examiner(s): TADESSE, YEWEBDAR T
• Application Number:
  US10/306,648
• Time in Patent Office: 1,134 Days
• Field of Search: 118/620, 118/621, 118/629, 118/63, 118/634, 118/50, 118/309, 118/500, 118/628, 427/2.24, 427/2.1, 427/2.25, 427/2.28, 427/476, 427/457, 427/486, 361225-229
• US Class Current: 118/634
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

An apparatus and method for electrostatic loading of drugs on an implantable medical device is disclosed.

Claims

1. A system for depositing a drug onto a stent, comprising:

a chamber for housing a stent;

an electrical supply source in communication with the stent for applying an electrical charge to the stent; and

a system including an RF coil surrounding the stent for ionizing a drug within the chamber so that the drug is attracted to and deposited on the charged stent.

2. The system of claim 1, additionally comprising a pump in fluid communication with the chamber for adjusting the pressure of the chamber.

3. The system of claim 2, additionally comprising a trap positioned between the pump and the chamber for capturing particles of the drug.

4. The system of claim 2, wherein the pump is a turbo pump, a mechanical rough pump or a cryo pump.

5. The system of claim 1, wherein the stent is supported by a support member.

6. The system of claim 5, wherein the support member is in communication with the electrical supply source for applying the electrical charge to the stent.

7. The system of claim 1, additionally comprising a mesh tube disposed between the stent and the RF coil, the mesh tube capable of receiving a charge for collecting charged particles around the stent.

8. The system of claim 7, wherein the mesh tube is in communication with the electrical supply source or is in communication with a second electrical supply source.

9. A system for depositing a drug onto a stent, comprising a drug applicator for directing a drug towards a stent and a system including a coil surrounding the stent for charging the drug so that the drug is attracted to and deposited onto the stent.

10. The system of claim 9, additionally comprising:

a chamber for housing the stent

a pump in fluid communication with the chamber for adjusting the pressure of the chamber; and

a trap positioned between the pump and the chamber for capturing particles of the drug.

11. The system of claim 10, wherein the pump is a turbo pump, a mechanical rough pump or a cryo pump.

12. The system of claim 9, wherein the drug applicator comprises a drug reservoir in communication with a gas source.

13. The system of claim 9, wherein the stent is supported by a support member.

14. The system of claim 13, wherein the support member is in communication with an electrical supply source for applying an electrical charge to the stent.

15. The system of claim 9, additionally comprising an electrical supply source in communication with the stent for applying an electrical charge to the stent.

16. The system of claim 9, additionally comprising a collecting member around the stent, the collecting member capable of receiving a charge for collecting charged particles around the stent.

17. The system of claim 16, wherein the collecting member is located between the stent and the coil.

18. A system for depositing a drug onto an implantable medical device, comprising:

a support member for supporting a medical device;

an electrical supply source in communication with the support member for applying an electrical charge to the medical device;

a system capable of charging a drug so that the drug is attracted to and deposited on the charged medical device; and

a collecting member circumscribing the medical device, the collecting member capable of receiving a charge for collecting charged particles around the medical device.

19. A system for depositing a drug onto an implantable medical device, comprising:

a support member for supporting a medical device;

an electrical supply source in communication with the support member for applying an electrical charge to the medical device; and

a system capable of charging a drug so that the drug is attracted to and deposited on the charged medical device, wherein the system capable of charging the drug includes a coil surrounding the medical device.

20. A system for depositing a drug onto a stent, comprising:

a chamber for housing a stent;

a drug applicator for directing drug particles towards the stent;

means for charging the drug particles directed towards the stent, the means for charging the drug particles including an RF coil; and

a collecting member positioned adjacent to the stent for collecting the charged drug particles around the stent.

21. The system of claim 20, wherein the drug applicator includes a drug source in communication with a gas source.

22. The system of claim 20, additionally comprising means for controlling the pressure in the chamber.

23. The system of claim 20, additionally comprising means for applying a charge to the stent and/or the collecting member.

24. The system of claim 20, wherein the collecting member is positioned between the RF coil and the stent.

25. A system for depositing a drug onto a stent, comprising:

a chamber for housing a stent;

a drug applicator for directing drug particles towards the stent;

means for charging the drug particles directed towards the stent; and

a collecting member positioned adjacent to the stent for collecting the charged drug particles around the stent, wherein the collecting member is a mesh body.

26. The system of claim 25, additionally comprising means for applying a charge to the stent and/or the collecting member.

27. A system for depositing a drug onto a stent, comprising:

a chamber for housing a stent;

a drug applicator for directing a drug towards the stent, such that the drug is caused to be charged so that the drug is deposited on the stent;

an RF coil for charging the drug; and

a collecting member positioned adjacent to the stent for collecting charged particles around the stent.

28. The system of claim 27, wherein the collecting member is positioned between the RF coil and the stent.

29. The system of claim 27, additionally including means for adjusting the pressure in the chamber.

30. The system of claim 27, wherein the drug applicator includes a drug source and a gas source.

31. The system of claim 27, additionally comprising means for applying a charge to the stent and/or the collecting member.

32. A system for depositing a drug onto a stent, comprising:

a chamber for housing a stent;

a drug applicator for directing a drug towards the stent, such that the drug is caused to be charged so that the drug is deposited on the stent; and

a collecting member positioned adjacent to the stent for collecting charged particles around the stent, wherein the collecting member is a mesh tube.

33. The system of claim 32, additionally including means for charging the drug.

34. The system of claim 32, additionally comprising means for applying a charge to the stent and/or the collecting member.