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High speed parallel molecular nucleic acid sequencing

  • US 6,982,146 B1
  • Filed: 08/29/2000
  • Issued: 01/03/2006
  • Est. Priority Date: 08/30/1999
  • Status: Expired due to Fees
First Claim
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1. A method of sequencing a sample nucleic acid molecule, comprising:

  • exposing the sample nucleic acid molecule to an oligonucleotide primer and a polymerase in the presence of a mixture of different nucleotides, wherein the polymerase and the nucleotides each comprise a fluorophore which emits a signal corresponding to addition of a particular nucleotide as each nucleotide is incorporated into a synthesized nucleic acid molecule which is complementary to the sample nucleic acid molecule; and

    detecting the signal as each nucleotide is incorporated into the synthesized nucleic acid molecule.

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