Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
First Claim
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1. A method for preventing or ameliorating a decrease in a function of a tissue, wherein the tissue has undergone an ischemia-reperfusion event sufficient to cause cell death, or reversible or irreversible cell damage in said tissue, comprising administering to an individual an effective amount of a composition comprising a compound that activates a receptor for glucagon-like peptide-1 (GLP-1) in a pharmaceutical carrier.
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Abstract
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like peptide-1. The invention relates to both the method and compositions for such treatment.
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Citations
28 Claims
- 1. A method for preventing or ameliorating a decrease in a function of a tissue, wherein the tissue has undergone an ischemia-reperfusion event sufficient to cause cell death, or reversible or irreversible cell damage in said tissue, comprising administering to an individual an effective amount of a composition comprising a compound that activates a receptor for glucagon-like peptide-1 (GLP-1) in a pharmaceutical carrier.
- 11. A method for preventing or ameliorating a decrease in a function of a tissue, wherein the tissue has undergone an ischemia-reperfusion event sufficient to cause cell death, or reversible or irreversible cell damage in said tissue, comprising administering to an individual an effective amount of an exendin.
- 23. A method for preventing or ameliorating tissue injury caused by reperfusion of blood flow following a period of ischemia, comprising administering to an individual an effective amount of a compound that activates a receptor for glucagon-like peptide-1.
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