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Fibrin binding moieties useful as imaging agents

  • US 6,984,373 B2
  • Filed: 12/21/2001
  • Issued: 01/10/2006
  • Est. Priority Date: 12/23/2000
  • Status: Active Grant
First Claim
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1. An isolated polypeptide having the ability to bind to fibrin, the polypeptide comprising the amino acid sequence:

  • Cys-X2-X3-X4-X5-X6-X7-X8-Cys (SEQ ID NO;

         2), wherein X2 is Pro, Arg, Asn, Asp, Gln, Gly, Phe, Ser, Thr, or Tyr;

    X3 is Ala, Asn, Asp, Gln, Glu, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, or Val;

    X4 is Glu, Gly, Lys, Ser, or Tyr;

    X5 is Pro, Asp, Glu, Asn, Gln, Gly, Leu, Lys, Ser, Thr, or Tyr;

    X6 is Arg, Gly, or Trp;

    X7 is Leu, Ile, Lys, Met, Asn, Gln, Pro, Ser, Thr, or Val; and

    X8 is Ile, Leu, Phe, Trp, or Tyr.

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