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Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins

  • US 6,984,383 B1
  • Filed: 07/27/2000
  • Issued: 01/10/2006
  • Est. Priority Date: 02/12/1999
  • Status: Expired due to Fees
First Claim
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1. A method for transplanting cells to a patient in need thereof, comprising:

  • a) obtaining cells from a donor,b) obtaining recipient cells from the patient;

    c) contacting the donor cells with an immunoglobulin specific to B7-1 and an immunoglobulin specific to B7-2, wherein the immunoglobulin specific to B7-2 has a binding affinity of at least about 107 M

    1
    , and wherein said immunoglobulin comprises an antigen binding region of non-human origin and at least a portion of an immunoglobulin of human origin, further wherein the antigen binding region of non-human origin comprises at least one framework region containing a substitution of at least one amino acid to a corresponding amino acid in the III2R heavy chain framework region or the H2F light chain framework region;

    d) combining b) and c) to form a mixture, ande) introducing the mixture of step d) to the patient.

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