Tendon-inducing compositions

• US 6,984,623 B2
• Filed: 02/18/2004
• Issued: 01/10/2006
• Est. Priority Date: 12/07/1993
• Status: Expired due to Fees

• Current Assignee: Genetics Institute Institute LLC, President and Fellows of Harvard College (Harvard Corporation)
• Original Assignee: Genetics Institute Institute LLC, President and Fellows of Harvard College (Harvard Corporation)
• Inventors: Melton, Douglas A., Wolfman, Neil M., Wozney, John M., Rosen, Vicki A., Thomsen, Gerald H., Celeste, Anthony J.
• Primary Examiner(s): KEMMERER, ELIZABETH
• Application Number:
  US10/779,635
• Publication Number:
  US 20040146923A1
• Time in Patent Office: 692 Days
• Field of Search: 514/2, 514/12, 424/85.1, 536/23.1, 536/23.5
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/386 Ligaments, tendons
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C07K 2319/02 containing a signal sequence

Abstract

Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.

Claims

1. A method for treating tendonitis comprising administering an effective amount of a protein selected from the group consisting of BMP-12, BMP-13, and MP-52 to a patient in need of same.

2. The method of claim 1, wherein the protein administered is BMP-12.

3. The method of claim 1, wherein the protein administered is BMP-13.

4. The method of claim 1, wherein the protein administered is MP-52.

5. A method for treating carpal tunnel syndrome comprising administering administering an effective amount of a protein selected from the group consisting of BMP-12, BMP-13, and MP-52 to a patient in need of same.

6. The method of claim 5, wherein the protein administered is BMP-12.

7. The method of claim 5, wherein the protein administered is BMP-13.

8. The method of claim 5, wherein the protein administered is MP-52.

9. A method for treating a tendon and/or ligament defect in patient comprising administering an effective amount of a protein selected from the group consisting of BMP-12, BMP-13, and MP-52 to a patient in need of same.

10. The method of claim 9, wherein the protein administered is BMP-12.

11. The method of claim 9, wherein the protein administered is BMP-13.

12. The method of claim 9, wherein the protein administered is MP-52.