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Fluorescence dyes and their applications for whole-cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof

  • US 6,984,718 B2
  • Filed: 05/06/2002
  • Issued: 01/10/2006
  • Est. Priority Date: 07/21/1998
  • Status: Expired due to Fees
First Claim
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1. A compound having the following structural formula:

  • embedded imageor a biologically acceptable salt or pro-reporter molecule thereof, wherein;

    X is a peptide comprising aspartic acid and an N-terminal protecting group;

    R8 and R9 are each independently selected from the group consisting of hydrogen, alkyl and aryl;

    R10 and R11 are each independently selected from the group consisting of hydrogen and alkyl;

    R1-R5 are each independently hydrogen, fluoro, chloro, bromo, iodo, haloalkyl, aryl, cycloalkyl, alkyl, alkenyl, alkynyl, aralkyl, aralkenyl, aryl alkynyl, hydroxyalkyl, nitro, amino, cyano, acylamino, acyl, hydroxy, acyloxy, alkoxy, alkylthio, and carboxy;

    provided that at least one of R1, R3 and R5 is selected from the group consisting of fluoro and chloro; and

    provided that said N-terminal protecting group is not an acetyl group.

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