Method for measuring venous oxygen saturation

• US 6,985,763 B2
• Filed: 11/30/2001
• Issued: 01/10/2006
• Est. Priority Date: 01/19/2001
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.), Tufts University
• Original Assignee: Tufts University
• Inventors: Fantini, Sergio, Boas, David, Franceschini, Maria Angela
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/466,447
• Publication Number:
  US 20040122300A1
• Time in Patent Office: 1,502 Days
• Field of Search: 600/310, 600/322, 600/323, 600/330, 600/336
• US Class Current: 600/323
• CPC Class Codes: A61B 5/02152 specially adapted for venous pressure
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6828 Leg
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427

Abstract

A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (6). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (8). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.

Claims

1. A method for measuring the venous oxygen saturation comprising the steps of:

illuminating an area of tissue of a subject with intensity modulated light at at least two wavelengths, said subject being free from mechanical ventilation devices and free from venous perturbations

sensing diffusely reflected light caused by said illumination to acquire time resolved measurement data; and

processing said time resolved measurement data to determine the absolute saturation of the venous compartment, said processing comprising at least determining an amplitude of respiration induced absorption oscillations.

2. A method for measuring the venous oxygen saturation as in claim 1 wherein:

the processing step comprises determining at least amplitudes for oxygenated and deoxygenated hemoglobin oscillations at the respiratory frequency.

3. A method for measuring the venous oxygen saturation as in claim 1 wherein:

the step of sensing diffusely reflected light comprises sensing diffusely reflected light at a plurality of wavelengths; and

wherein

the processing step comprises determining an amplitude of respiration induced absorption oscillations at each of said plurality of wavelengths.

4. A method for measuring the venous oxygen saturation as in claim 3 wherein said plurality of wavelengths comprises at least eight.

5. A method for measuring the venous oxygen saturation as in claim 1 wherein:

the processing step comprises quantifying said amplitude of absorption oscillations at said respiratory frequency using a fast Fourier transformation.

6. A method for measuring the venous oxygen saturation as in claim 5 wherein the method comprises acquiring time resolved measurement data over at least 10 respiratory cycles.

7. A method for measuring the venous oxygen saturation as in claim 1 wherein:

the processing step comprises quantifying said amplitude of absorption oscillations at said respiratory frequency by using a band pass filter to isolate said absorption oscillations at said respiratory frequency and subsequently applying a modeling algorithm to said absorption oscillations over each respiratory cycle.

8. A method for measuring the venous oxygen saturation as in claim 7 wherein said modeling algorithm comprises a sin wave fitting algorithm.

9. A method for measuring the venous oxygen saturation as in claim 1 wherein the method further comprises the step of verifying that said absorption oscillations at said at least two wavelengths occur in phase at said respiratory frequency.

10. A method for measuring the venous oxygen saturation as in claim 1 wherein the method further comprises placing a probe on said area of tissue, said probe for generating said intensity modulated light for illuminating said area of tissue, and wherein said probe is placed directly over a visible vein.

11. A method for measuring the venous oxygen saturation as in claim 1 wherein the step of processing said time resolved measurement data comprises determining an amplitude of absorption oscillations at the heartbeat frequency and verifying that the amplitude of said heartbeat frequency absorption oscillations is less than the amplitude of said respiration induced absorption oscillations.

12. A method for measuring the venous oxygen saturation as in claim 1 wherein the step of processing said time resolved measurement data comprises determining absorption data, and wherein the method further comprises verifying that a hemoglobin spectrum closely agrees with said absorption data.

13. A method for measuring the venous oxygen saturation as in claim 1 wherein said steps of illuminating and sensing are conducted on a common side of said area of tissue.

14. A method for measuring the venous oxygen saturation as in claim 1 wherein said processing step comprises fitting said amplitude of respiration induced absorption oscillations with a linear combination of extinction spectra of oxygenated and deoxygenated hemoglobin.

15. A method for measuring the venous oxygen saturation as in claim 1 wherein said processing step comprises determining an effective optical path length between an illumination source and an illuminated point in said illuminated area of tissue, said effective optical path length being used to determine said amplitude of respiration induced absorption oscillations.

16. A method for measuring the venous oxygen saturation as in claim 1 wherein said processing step comprises determining a tissue scattering coefficient and a tissue absorption coefficient, said scattering coefficient and said absorption coefficient being used to determine said amplitude of respiration induced absorption oscillations.

17. A method for measuring the venous oxygen saturation as in claim 1 wherein the time resolved data processing step comprises:

determining a reduced scattering coefficient and an absorption coefficient for said tissue; and

using said reduced scattering coefficient and said absorption coefficient to determine an effective optical path length between an illumination source and an illuminated point in said illuminated area of tissue, said effective optical path length being used to determine said amplitude of respiration induced absorption oscillations.

18. A method for measuring a venous oxygen saturation comprising the steps of:

illuminating an area of tissue of a subject with intensity modulated light in the visible and near infrared spectral range at at least two wavelengths on a common side of said area of tissue;

sensing diffusely reflected light caused by said illumination to acquire time resolved measurement data for each of said at least two wavelengths; and

processing said time resolved measurement data at each of said at least two wavelengths to determine the absolute saturation of the venous compartment, said processing comprising determining a reduced scattering coefficient and an oscillation absorption coefficient, quantifying an amplitude of respiration induced absorption oscillations using said reduced scattering coefficient and said oscillation absorption coefficient and using one of either a Fourier transformation or a band pass filter, and fitting said amplitude of respiration induced absorption oscillations with a linear combination of extinction spectra of oxygenated and deoxygenated hemoglobin.

19. A method for measuring a venous oxygen saturation level as in claim 18 wherein said subject being free from mechanical ventilation devices and venous perturbation.

20. A method for measuring the venous oxygen saturation comprising the steps of:

illuminating an area of tissue with a probe generating intensity modulated light at a plurality of wavelengths;

sensing diffusely reflected light caused by said illumination to acquire time resolved measurement data;

processing said time resolved measurement data to determine the absolute saturation of the venous compartment, said processing comprising at least determining an amplitude of respiration induced absorption oscillations; and

verifying that said measurement data is accurate.

21. A method for measuring the venous oxygen saturation as in claim 20 wherein the step of verifying that said measurement data is accurate comprises measuring time resolved absorption oscillation data at said plurality of wavelengths and verifying that said oscillations are in phase at the respiratory frequency.

22. A method for measuring the venous oxygen saturation as in claim 20 wherein the step of verifying that said measurement data is accurate comprises verifying that said probe is located directly over a visible vein.

23. A method for measuring the venous oxygen saturation as in claim 20 wherein the step of verifying that said measurement data is accurate comprises determining amplitudes of oxygenated and deoxygenated hemoglobin concentration oscillations at a heartbeat frequency and at a respiratory frequency, and verifying that said amplitudes at said heartbeat frequency are less than said amplitudes at said respiratory frequency.

24. A method for measuring the venous oxygen saturation as in claim 20 wherein the step of processing said time resolved data comprises determining absorption data, and wherein the step of verifying that said measurement data is accurate comprises verifying that a hemoglobin spectrum closely agrees with said absorption data.

25. A computer program product for causing a computer to measure the venous oxygen saturation, the program product comprising computer executable instructions stored on a computer readable medium, the program instructions when executed causing the computer to:

illuminate an area of tissue using a probe generating intensity modulated light at a plurality of wavelengths;

sense diffusely reflected light caused by said illumination to acquire time resolved measurement data;

process said time resolved measurement data to determine the absolute saturation of the venous compartment, said processing comprising at least determining an amplitude of respiration induced absorption oscillations; and

verify that said time resolved measurement data represents venous compartment data.

26. A computer program product as in claim 25, wherein the program instructions when executed cause the computer to verify that said probe is properly located by causing the computer to perform one or more of the steps from the group of steps consisting of:

measuring time resolved absorption oscillation data at said plurality of wavelengths and verifying that said oscillations are in phase at the respiratory frequency, and determining amplitudes of oxygenated and deoxygenated hemoglobin concentration oscillations at a heartbeat frequency and at a respiratory frequency and verifying that said amplitudes at said heartbeat frequency are less than said amplitudes at said respiratory frequency.

27. A computer program product as in claim 25 said program instructions being operable when said subject is free from mechanical ventilation devices and venous perturbation.