Physiological event detection

• US 6,985,768 B2
• Filed: 02/28/2003
• Issued: 01/10/2006
• Est. Priority Date: 02/28/2003
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Hemming, Michael T., Hamilton, John R., Hansen, Daniel L., Samuelson, Kent
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US10/376,920
• Publication Number:
  US 20040171953A1
• Time in Patent Office: 1,047 Days
• Field of Search: 607 1- 28, 600508-547
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

In general, the invention is directed to techniques for electrically detecting physiological events. The physiological events may include cardiac events such as R waves or p waves. In addition, the physiological events may include respiratory events. In general, the techniques involve converting an analog physiological signal to a digital delta value, correlating the digital delta value with a correlation template, and detecting a physiological event based on an output of the correlation. A digital correlation-based technique, as described herein, is implemented to reliably detecting physiological events, particularly for very small signals captured in the presence of significant background noise.

Claims

1. A physiological event detector comprising:

a delta converter to convert an analog physiological signal to a digital delta value representative of a slope of the analog physiological signal;

a correlator to correlate the digital delta value with a correlation template; and

an event detector to detect a physiological event based on an output of the correlation circuit.

2. The detector of claim 1, wherein the physiological event is a cardiac event.

3. The detector of claim 2, wherein the cardiac event is an R wave.

4. The detector of claim 2, wherein the cardiac event is a p wave.

5. The detector of claim 1, wherein the physiological event is a respiratory event.

6. The detector of claim 1, wherein the event detection circuit includes a threshold detection circuit that compares the output of the correlation circuit to a threshold value and detects the physiological event based on the comparison.

7. The detector of claim 6, further comprising an absolute value circuit to produce an absolute value of the output of the correlation circuit, wherein the threshold detection circuit detects the physiological event if the absolute value of the output of the correlation circuit is greater than or equal to the threshold value.

8. The detector of claim 6, wherein the threshold detection circuit detects the physiological event when the output of the correlation circuit produces a first slope that exceeds the threshold followed by a second slope that exceeds the threshold within a window associated with the correlation template.

9. The detector of claim 1, wherein the event detection circuit includes a peak detection circuit that detects a peak of the output of the correlation circuit, and detects the physiological event in response to the detection of the peak.

10. The detector of claim 9, further comprising an absolute value circuit to produce an absolute value of the output of the correlation circuit, wherein the peak detection circuit detects the physiological event based on the absolute value of the output of the correlation circuit.

11. The detector of claim 9, wherein the peak detection circuit detects the physiological event when the output of the correlation circuit produces a positive peak slope followed by a negative peak slope within a window associated with the correlation template.

12. The detector of claim 1, wherein the event detection circuit includes a slope segmenter that classifies the output of the correlation circuit into slope segments, and a discrimination circuit that analyzes the slope segments to detect the physiological event.

13. The detector of claim 12, wherein the discriminator detects p waves based on widths of the slope segments.

14. The detector of claim 1, further comprising a smoothing filter to smooth the digital delta value.

15. The detector of claim 1, wherein the digital delta value forms an input vector, the correlation template forms a slope template vector, and the output of the correlation circuit is a sum of a product of the input vector and the slope template vector over a plurality of samples of the digital delta value.

16. A method comprising:

converting an analog physiological signal to a digital delta value representative of a slope of the analog physiological signal;

correlating the digital delta value with a correlation template; and

detecting a physiological event based on an output of the correlation.

17. The method of claim 16, wherein the physiological event is a cardiac event.

18. The method of claim 17, wherein the cardiac event is an R wave.

19. The method of claim 17, wherein the cardiac event is a p wave.

20. The method of claim 16, wherein the physiological event is a respiratory event.

21. The method of claim 16, further comprising comparing the output of the correlation to a threshold value and detecting the physiological event based on the comparison.

22. The method of claim 21, further comprising producing an absolute value of the output of the correlation, and detecting the physiological event if the absolute value of the output of the correlation is greater than or equal to the threshold value.

23. The method of claim 21, wherein detecting the physiological event includes detecting the physiological event when the output of the correlation circuit produces a first slope that exceeds the threshold followed by a second slope that exceeds the threshold within a window associated with the correlation template.

24. The method of claim 16, further comprising detecting a peak of the output of the correlation, and detecting the physiological event in response to the detection of the peak.

25. The method of claim 24, further comprising producing an absolute value of the output of the correlation, and detecting the physiological event based on the absolute value of the output of the correlation.

26. The method of claim 24, further comprising detecting the physiological event when the output of the correlation produces a positive peak slope followed by a negative peak slope within a window associated with the correlation template.

27. The method of claim 16, further comprising classifying the output of the correlation into slope segments, and analyzing the slope segments to detect the physiological event.

28. The method of claim 27, further comprising detecting p waves based on widths of the slope segments.

29. The method of claim 16, further comprising a smoothing the digital delta value with a smoothing filter.

30. The method of claim 16, wherein the digital delta value forms an input vector, the correlation template forms a slope template vector, and the output of the correlation is a sum of a product of the input vector and the slope template vector over a plurality of samples of the digital delta value.

31. A physiological event detector comprising:

means for converting an analog physiological signal to a digital delta value representative of a slope of the analog physiological signal;

means for correlating the digital delta value with a correlation template; and

means for detecting a physiological event based on an output of the correlation.

32. The detector of claim 31, wherein the physiological event is a cardiac event.

33. The detector of claim 32, wherein the cardiac event is an R wave.

34. The detector of claim 32, wherein the cardiac event is a p wave.

35. The detector of claim 31, wherein the physiological event is a respiratory event.

36. The detector of claim 31, further comprising comparing the output of the correlation to a threshold value and detecting the physiological event based on the comparison.

37. The detector of claim 36, further comprising means for producing an absolute value of the output of the correlation, and means for detecting the physiological event if the absolute value of the output of the correlation is greater than or equal to the threshold value.

38. The detector of claim 36, wherein the means for detecting the physiological event includes means for detecting the physiological event when the output of the correlation circuit produces a first slope that exceeds the threshold followed by a second slope that exceeds the threshold within a window associated with the correlation template.

39. The detector of claim 31, further comprising means for detecting a peak of the output of the correlation, and means for detecting the physiological event in response to the detection of the peak.

40. The detector of claim 39, further comprising means for producing an absolute value of the output of the correlation, and means for detecting the physiological event based on the absolute value of the output of the correlation.

41. The detector of claim 39, further comprising means for detecting the physiological event when the output of the correlation produces a positive peak slope followed by a negative peak slope within a window associated with the correlation template.

42. The detector of claim 31, further comprising means for classifying the output of the correlation into slope segments, and means for analyzing the slope segments to detect the physiological event.

43. The detector of claim 42, further comprising means for detecting p waves based on widths of the slope segments.

44. The detector of claim 31, further comprising means for smoothing the digital delta value with a smoothing filter.

45. The detector of claim 31, wherein the digital delta value forms an input vector, the correlation template forms a slope template vector, and the output of the correlation is a sum of a product of the input vector and the slope template vector over a plurality of samples of the digital delta value.