Dry powder dose filling systems and related methods
First Claim
1. A method of flowably dispensing pharmaceutical dry powder from a hopper during a filling operation, the hopper having a dispensing port and a dry powder flow path, comprising:
- generating a first non-linear vibration input signal, the first non-liner input signal comprising a carrier frequency modulated by a plurality of different selected predetermined modulating frequencies that correspond to a first dry powder formulation;
applying the first non-linear vibration input signal to a dispensing hopper having a dry powder flow path and at least one dispensing port while the first dry powder formulation is flowing therethrough; and
dispensing a first meted quantity of the first dry powder through the dispensing port to a receiving member.
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Abstract
Methods for flowably dispensing dry powders from a hopper having a dispensing port and a dry powder flow path can include: (a) generating a first non-linear vibration input signal, the first non-linear input signal comprising a plurality of different selected frequencies that correspond to a first dry powder formulation; (b) applying the first non-linear vibration input signal to a dispensing hopper having at least one dispensing port while the first dry powder formulation is flowing therethrough; and (c) dispensing a first meted quantity of the first dry powder through the dispensing port to a receiving member. Related devices and computer program products for dispensing dry powders are also described.
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Citations
48 Claims
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1. A method of flowably dispensing pharmaceutical dry powder from a hopper during a filling operation, the hopper having a dispensing port and a dry powder flow path, comprising:
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generating a first non-linear vibration input signal, the first non-liner input signal comprising a carrier frequency modulated by a plurality of different selected predetermined modulating frequencies that correspond to a first dry powder formulation; applying the first non-linear vibration input signal to a dispensing hopper having a dry powder flow path and at least one dispensing port while the first dry powder formulation is flowing therethrough; and dispensing a first meted quantity of the first dry powder through the dispensing port to a receiving member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 48)
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29. A method of operating a dry powder filling system for dispensing pharmaceutical grade formulations of inhalable dry powder substances to target receiving members, comprising:
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generating a vibratory signal comprising a carrier frequency modulated by a plurality of selected predetermining modulating frequencies to dry powder in a bulk powder enclosure having a dispensing flow path, the selected modulating frequencies corresponding to identified a priori flow characteristic frequencies of the dry powder; and dispensing meted quantities of the dry powder using the generated vibratory signal. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of flowably dispensing production batches of pharmaceutical dry powders from a hopper having a dispensing port and a dry powder flow path, comprising:
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generating a first vibration input signal, the first input signal comprising a carrier frequency modulated by at least one selected predetermined modulating frequency, the selected modulating frequency generally corresponding to one of a plurality of a priori identified flow characteristic frequencies of a particular dry powder being dispensed; applying the first vibration input signal to the dry powder while the first dry powder formulation is flowing so that the first input signal vibrates the powder in a flow path to facilitate fluidic flow of the dry powder; and serially dispensing meted quantities of the first dry powder to at least one receiving member, wherein a dose to dose variation of the meted quantities is less than about 5%. - View Dependent Claims (43, 44)
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45. A method of flowably dispensing pharmaceutical dry powder(s) from a hopper and/or dry powder flow path that merges into a dispensing port comprising;
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generating a first non-linear vibration input signal, the first non-linear input signal comprising a carrier frequency modulated by a plurality of different selected predetermined modulating frequencies, the different selected modulating frequencies corresponding to flow characteristic frequencies derived from a flow analysis of a dry powder formulation targeted for dispensing; applying the first non-linear vibration input signal to the dry powder while the dry powder formulation is flowing; and dispensing meted quantities of the first dry powder through a dispensing port to a receiving member. - View Dependent Claims (46, 47)
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Specification