Method for measurement of systolic and diastolic time intervals

• US 6,986,741 B2
• Filed: 04/08/2003
• Issued: 01/17/2006
• Est. Priority Date: 04/08/2002
• Status: Expired due to Fees

• Current Assignee: Medwave, Inc.
• Original Assignee: Medwave, Inc.
• Inventors: O'Malley, Timothy J., Poliac, Liviu C., Poliac, Marius O.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/409,669
• Publication Number:
  US 20030216653A1
• Time in Patent Office: 1,015 Days
• Field of Search: 600500-503, 600/481, 600/483, 600/485, 600/486, 600/490, 600492-496
• US Class Current: 600/485
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Abstract

A method and apparatus for determining cardiac time intervals that can measure physiological data noninvasively. Arterial pulse values are measured either invasively or noninvasively, from which left ventricular waveform data is generated. Systolic and diastolic time intervals are derived based on the left ventricular waveform data.

Claims

1. A method of determining cardiac time intervals of a patient, the method comprising:

measuring arterial pulse values;

extrapolating left ventricular waveform data from the arterial pulse values;

identifying main cardiac events based on the left ventricular waveform data; and

deriving systolic and diastolic time intervals based on the main cardiac events.

2. The method of claim 1 wherein the arterial pulse values are measured noninvasively.

3. The method of claim 1 wherein the arterial pulse valves are measured invasively.

4. The method of claim 1 wherein the arterial pulse is a radial pulse.

5. The method of claim 1 wherein the main cardiac events include isovolumic contraction time, left ventricular ejection time;

isovolumic relaxation time, and rapid filling time.

6. The method of claim 1 wherein identifying the main cardiac events further comprises:

generating an arterial pulse waveform from the arterial pulse values;

extrapolating the left ventricular waveform data from a portion of the arterial pulse waveform; and

identifying a point where the left ventricular waveform data intersects with a preselected constant pressure, wherein the identified point corresponds to one of the main cardiac events.

7. The method of claim 6 wherein the portion of the arterial pulse waveform produces waveforms for the left ventricular waveform data that are selected from the group consisting of first order linear, second order linear, and exponential waveforms.

8. The method of claim 1 and further comprising:

measuring changes in the cardiac time intervals for early detection of cardiovascular disease.

9. The method of claim 1 and further comprising:

infusing the patient with pharmacological agents; and

measuring changes in the systolic and diastolic time intervals of the patient.

10. The method of claim 1 wherein the arterial pulse values are arterial blood pressure values.

11. The method of claim 1 and further comprising:

generating arterial pulse waveform data based on the arterial pulse values; and

using the arterial pulse waveform data to generate the left ventricular waveform data.

12. The method of determining cardiac information of a patient, the method comprising:

measuring arterial pulse values; and

extrapolating left ventricular waveform data from the arterial pulse values.

13. The method of claim 12 wherein the arterial pulse values are based on arterial pulse blood pressure values.

14. An apparatus for determining cardiac time intervals, the apparatus comprising:

an arterial pressure measurement device;

means for generating arterial pulse waveform data;

means for extrapolating left ventricular waveform data;

means for identifying main cardiac events; and

means for deriving systolic and diastolic time intervals.

15. The apparatus in claim 14 wherein the arterial pressure measurement device is a noninvasive blood pressure measurement device.

16. The apparatus of claim 14 wherein the arterial pressure measurement device is an invasive arterial line.

17. The apparatus of claim 14 wherein the means for identifying main cardiac events further comprises:

software for identifying the main cardiac events from the arterial pulse waveform data and from the left ventricular waveform data.