Method of measuring the stress or relaxation level of a mammal

• US 6,986,747 B2
• Filed: 01/29/2003
• Issued: 01/17/2006
• Est. Priority Date: 01/29/2002
• Status: Expired due to Fees

• Current Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Inventors: Kollias, Nikiforos, Tierney, Neena, Wiegand, Benjamin, Dean, Kathryn, McCulloch, Laura
• Primary Examiner(s): Winakur, Eric F.
• Application Number:
  US10/353,525
• Publication Number:
  US 20030220550A1
• Time in Patent Office: 1,084 Days
• Field of Search: 600/310, 600/322, 600/323, 600/336, 600552-555, 600557-559, 600 26- 28
• US Class Current: 600/558
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system

Abstract

A method of measuring the stress or relaxation level of a mammal and a method of measuring the activity of the sympathetic nervous system of a mammal by measuring quantititative levels of deoxyhemoglobin and oxyhemoglobin are disclosed. Preferably, the levels of deoxyhemoglobin and hemoglobin are measured by a noninvasive technique, such as spectroscopy. A method of changing the activity of the sympathetic nervous system of a mammal is also disclosed, wherein the method includes a step of administering an effective amount of sensory regimen to the mammal. The method is useful for humans who are operating vehicles or machinery, who are suffering from cardiovascular disease or related complications, who are pregnant, or who are preparing for sleep. In addition, a method of improving the complexion of the skin of a mammal is disclosed.

Claims

1. A method of measuring the stress or relaxation level of a mammal, comprising the step of:

a. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal prior to exposing said mammal to an acute stressor or relaxor;

b. exposing said mammal to said acute stressor or relaxor;

c. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal during or after said exposing step; and

d. for step a and step c, calculating and comparing at least one ratio selected from the group consisting of;

i. the ratio of the level of deoxyhemoglobin to the level of oxyhemoglobin of said mammal; and

ii. the ratio of the level of deoxyhemoglobin to the sum of the level of deoxyhemoglobin and the level of oxyhemoglobin of said mammal.

3. The method of claim 1 or 2, wherein said level of deoxyhemoglobin and said level of oxyhemoglobin are measured by at least one noninvasive technique.

4. The method of claim 3, wherein said technique is spectroscopy.

5. The method of claim 4, wherein said spectroscopy is at least one technique selected from the group consisting of diffuse reflectance spectroscopy, near infrared spectroscopy and ultraviolet-visible spectroscopy.

2. A method of measuring the activity of the sympathetic nervous system of a mammal, comprising the steps of:

a. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal prior to exposing said mammal to an acute stressor or relaxor;

b. exposing said mammal to said acute stressor or relaxor;

c. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal during or after said exposing step; and

d. for step a and step c, calculating and comparing at least one ratio selected from the group consisting of;

i. the ratio of the level of deoxyhemoglobin to the level of oxyhemoglobin of said mammal; and

ii. the ratio of the level of deoxyhemoglobin to the sum of the level of deoxyhemoglobin and the level of oxyhemoglobin of said mammal.

6. A method of changing the stress or relaxation level of a mammal, comprising the steps of:

a. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal prior to exposing said mammal to an acute stressor or relaxor;

b. exposing said mammal to said acute stressor or relaxor;

c. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal during or after said exposing step;

d. for step a and step c, calculating and comparing at least one ratio selected from the group consisting of;

i. the ratio of the level of deoxyhemoglobin to the level of oxyhemoglobin of said mammal; and

ii. the ratio of the level of deoxyhemoglobin to the sum of the level of deoxyhemoglobin and the level of oxyhemoglobin of said mammal; and

e. changing at least one of said ratios before and after step b by at least 1% by administering an effective amount of a sensory regimen.

8. The method of claim 6 or claim 7, wherein at least one of said ratios before and after step b is changed by at least 5%.

9. The method of claim 6 or claim 7, wherein at least one of said ratios before and after step b is changed by at least 10%.

10. The method of claim 6 or claim 7, wherein said changing step e is a reduction.

11. The method of claim 6 or claim 7, wherein said changing step e is an increase.

12. The method of claim 6 or claim 7, wherein said mammal is a human operator of a vehicle or a machine.

13. The method of claim 12, further comprising the step of:

alerting said human operator of impaired ability to operate said vehicle or said machine.

14. The method of claim 6 or claim 7, wherein said mammal has cardiovascular disease or related complications.

15. The method of claim 6 or claim 7, wherein said mammal is pregnant.

16. The method of claim 6 or claim 7, wherein said mammal is preparing for sleep.

17. The method of claim 6 or claim 7, further comprising the step of:

alerting said mammal of a detrimental level of stress.

7. A method of changing the activity of the sympathetic nervous system of a mammal, comprising the steps of:

a. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal prior to exposing said mammal to an acute stressor or relaxor;

b. exposing said mammal to said acute stressor or relaxor;

c. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal during or after said exposing step;

d. for step a and step c, calculating and comparing at least one ratio selected from the group consisting of;

i. the ratio of the level of deoxyhemoglobin to the level of oxyhemoglobin of said mammal; and

ii. the ratio of the level of deoxyhemoglobin to the sum of the level of deoxyhemoglobin and the level of oxyhemoglobin of said mammal; and

e. changing at least one of said ratios before and after step b by at least 1% by administerinig an effective amount of a sensory regimen.

18. A method of improving the complexion of the skin of a mammal, comprising the steps of:

a. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal prior to exposing said mammal to an acute relaxor;

b. exposing said mammal to said acute relaxor;

c. measuring the level of oxyhemoglobin and the level of deoxyhemoglobin in the cutaneous blood supply of said mammal during or after said exposing step;

d. for step a and step c, calculating and comparing at least one ratio selected from the group consisting of;

i. the ratio of the level of deoxyhemoglobin to the level of oxyhemoglobin of said mammal; and

ii. the ratio of the level of deoxyhemoglobin to the sum of the level of deoxyhemoglobin and the level of oxyhemoglobin of said mammal; and

e. reducing at least one of said ratios before and after step b by at least 1% by administering an effective amount of a sensory regimen wherein said effective amount is effective to improve the complexion of the skin of said mammal.

19. The method of claim 18, wherein at least one of said ratios before and after step b is reduced by at least 5%.

20. The method of claim 19, wherein at least one of said ratios before and after step b is reduced by at least 10%.