Apparatus, systems and methods for processing and treating a biological fluid with light

• US 6,986,867 B2
• Filed: 07/29/2002
• Issued: 01/17/2006
• Est. Priority Date: 06/03/1999
• Status: Expired due to Term

• Current Assignee: Cerus Corporation, Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc.
• Inventors: Hanley, Kathleen A., Beittel, David F., Metzel, Peyton S., Franzosa, Paul A., Homza Stark, Daniela, Stark, Peter R. H., Power, Wendy M., Cimino, George D.
• Primary Examiner(s): JASTRZAB, KRISANNE MARIE
• Application Number:
  US10/207,744
• Publication Number:
  US 20030035751A1
• Time in Patent Office: 1,268 Days
• Field of Search: 422/24, 422/22, 422/29, 422/40, 422/41, 422/186.3, 422/25, 250/455.11, 435/2, 604/4, 206/29, 206/568, 206/570
• US Class Current: 422/22
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61L 2/0082 using chemical substances
• CPC Class Codes: A61L 2/084 Visible light
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: A61L 2/26 Accessories or devices or components used for biocidal treatment
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2202/22 Blood or products thereof
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus

Abstract

Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Claims

1. A method for treating a biological fluid comprising:

providing an apparatus including;

(a) a fluid treatment camber and at least one light source directed at said fluid treatment chamber;

(b) a tray for placement within said fluid treatment chamber, said tray comprising at least first and second adjacent compartments adapted for receiving a fluid processing set of two or more containers and means for accommodating a flow path joining said containers;

providing a disposable fluid processing set including a first container of a biological fluid integrally joined to a second container by a flow path;

locating said first container within said first compartment of said fluid treatment chamber substantially within the field of light;

locating said second container within said second compartment;

exposing said container of biological fluid to light from said light source;

agitating said biological fluid during exposing.

2. The method of claim 1 comprising locating at least two containers of said biological fluid within said fluid treatment chamber.

3. The method of claim 1 comprising separately monitoring the intensity of light contacting said biological fluid in each of said containers.

4. The method of claim 1 comprising marking said second container prior to said contacting.

5. The method of claim 2 comprising providing a tray for carrying said containers, said tray including a first portion for carrying a container of biological fluid and a second portion for carrying a container of biological fluid.

6. The method of claim 5 further comprising:

determining the type of biological fluid within said containers; and

automatically determining the type and duration of said exposing.

7. The method of claim 1 comprising determining the temperature of said fluid treatment chamber to ensure that said temperature is within a predetermined range.

8. The method of claim 1 comprising automatically terminating said contacting if said temperature exceeds said predetermined range.

9. The method of claim 1 comprising providing ambient air to said fluid treatment chamber.

10. The method of claim 1 comprising automatically terminating said contacting within said first portion without terminating said contacting within said second portion.

11. The method of claim 1 further comprising:

adding a photochemical agent to said biological fluid prior to said exposing; and

providing a sensor at or near said fluid treatment chamber, wherein said sensor has a maximum sensitivity in the wavelength range that substantially matches the wavelength range within which said photochemical agent is most effectively activated.

12. The method of claim 1 further comprising indicating the status of said first container exposure on said second container.

13. The method of claim 1 comprising substantially exposing said first container to light while substantially preventing exposure of said second container to light.