Apparatus and method for dispensing small quantities of particles

• US 6,987,228 B1
• Filed: 11/03/2000
• Issued: 01/17/2006
• Est. Priority Date: 11/05/1999
• Status: Expired due to Term

• Current Assignee: Pfizer Limited (Pfizer Inc.)
• Original Assignee: Powderject Research Limited (Pfizer Inc.)
• Inventors: Westland, Duncan, MacMichael, Bruce
• Primary Examiner(s): Gibson, Randy W.
• Application Number:
  US10/129,463
• Time in Patent Office: 1,901 Days
• Field of Search: 22/55, 22/56, 22/77, 177/105, 177/116, 177/119, 177/108, 141/83
• US Class Current: 177/116
• CPC Class Codes: G01G 13/04 involving dribble-feed means controlled by the weighing mechanism to top up the receptacle to the target weight
• CPC Class Codes: G01G 13/06 wherein the main feed is effected by gravity from a hopper or chute

Abstract

There is disclosed an apparatus and method which is capable of dispensing very small (typically less than 5 mg) quantities of particles to a high accuracy in a repeatable way and without undue wastage. Also, the need for advanced particle formulation is reduced. The apparatus comprises a closed loop control system which uses an electro-mechanical actuator to deliver impact energy to a supply of particles initially held on a sieve in a hopper. The impact energy causes a small number of particles to fall through the sieve and onto a weight measuring balance. The weight obtained is scrutinized by a processor to see if further actuations are required. In preferred embodiments, the energy of actuation is varied in accordance with the rate of dispensation calculated by the processor. Also, a correction amount can be obtained to take account of the fact that the balance can take a considerable amount of time to settle to its final value.

Claims

1. Apparatus for dispensing particles, comprising:

a particle retainer for retaining a supply of the particles to be dispensed, said particle retainer having a plurality of apertures arranged to be clogged by the particles and to be unclogged for dispensing therethrough of said particles;

a particle release actuator responsive to an actuation signal and arranged to vibrate the particle retainer in order to unclog said apertures so as to enable some of said supply of particles to be dispensed from said particle retainer through said unclogged apertures; and

a weight measuring device for measuring the apparent weight of particles dispensed from said particle retainer and for outputting a signal representing the measured apparent weight.

2. Apparatus according to claim 1, further comprising a processor operatively connected to said particle release actuator and arranged to output said actuation signal thereto and operatively connected to said weight measuring device and arranged to receive said measured apparent weight signal therefrom.

3. Apparatus according to claim 2, wherein said processor is arranged to reduce the effects of non-instantaneous working of said weight-measuring device by estimating the actual weight of particles dispensed, the estimation comprising said measured apparent weight added to a correction value.

6. Apparatus according to claim 2, wherein said processor is arranged to provide an actuation signal that has a characteristic corresponding to the amount of particles desired to be dispensed from said particle retainer upon receipt by said particle release actuator of that said signal.

7. Apparatus according to claim 2, wherein said processor comprises a timer and is operable to calculate from a signal output from said timer and said measured apparent weight the apparent rate at which said particles are being dispensed onto said weight measuring device.

8. Apparatus according to claim 7, wherein said processor is arranged to use the calculated apparent rate to obtain the correction value to be added to said measured apparent weight so as to estimate the actual weight of particles dispensed.

9. Apparatus according to claim 8, wherein said processor is arranged to multiply the calculated apparent rate by a time constant to obtain the or a correction value.

10. Apparatus according to claim 2, wherein said processor is arranged to calculate a correction value to be added to said measured apparent weight so as to estimate the actual weight of particles dispensed, said calculation comprising:

counting the number of times said particle release actuator is actuated within a defined time period; and

adding a stored standard weight to said correction value for each said actuation.

11. Apparatus according to claim 10, wherein said processor is further arranged to multiply each said stored standard weight by a multiplication factor of 1 or less, said multiplied standard weight being used instead of said standard weight when calculating said correction value.

12. Apparatus according to claim 11, wherein said multiplication factor is determined in accordance with the time during said defined time period that said particle release actuator is actuated.

13. Apparatus according to claim 11, wherein said multiplication factor is determined using a function which generally linearly decreases for increased times since the corresponding actuation of the particle release actuator.

14. Apparatus according to claim 10, wherein said processor is arranged to update the stored standard weight after the desired mass of particles has been dispensed.

15. Apparatus according to claim 14, wherein said updating comprises obtaining a value for the average weight of particles dispensed as a result of each actuation made the last time the apparatus was used to dispense particles.

16. Apparatus according to claim 15, wherein said value is obtained by dividing the total weight of dispensed particles by the number of actuations.

17. Apparatus according to claim 8, wherein said processor is arranged to compare said estimated actual dispensed weight with a predetermined weight of particles so as to decide whether the further dispensation of particles is necessary.

18. Apparatus according to claim 17, wherein said predetermined weight of particles comprises a desired weight of particles to be dispensed minus a tolerance weight.

19. Apparatus according to claim 7, wherein said processor is arranged to provide said particle release actuator with a signal to increase its energy of actuation when said calculated apparent rate is lower than a predetermined desired rate value.

20. Apparatus according to claim 7, wherein said processor is arranged to provide said particle release actuator with a signal to reduce its energy of actuation when said calculated apparent rate is higher than a predetermined desired rate value.

21. Apparatus according to claim 7, wherein said processor is arranged to pause for a predetermined period of time when said calculated apparent rate is higher than a predetermined desired rate value.

22. Apparatus according to claim 19, wherein said processor is arranged to reduce the efforts of non-instantaneous working of the weigh-measuring device by estimating the actual weight of particles dispensed, the estimation comprising said measured apparent weight added to a correction value and wherein said processor is arranged to reduce said predetermined desired rate value when one of said measured apparent weight and said estimated actual weight value are within a predetermined range of a predetermined weight of particles.

23. Apparatus according to claim 1, wherein said particle retainer comprises a hopper and said apertures are provided by a sieve across the cross-section of said hopper, said sieve being capable of supporting particles thereon.

24. Apparatus according to claim 1, wherein said apertures have a size larger than the average size of the particles to be dispensed, said apertures capable of being clogged by particles until said particle retainer is disturbed.

25. Apparatus according to claim 1, wherein said apertures are holes having a diameter of from 50 to 400 μ

m.

26. Apparatus according to claim 1, wherein said particle retainer comprises a single piece moulded plastics material hopper and sieve.

27. Apparatus according to claim 1, wherein said particle retainer comprises a stainless steel hopper and stainless steel sieve.

28. Apparatus according to claim 23, wherein said sieve has a diameter of about 3 mm.

29. Apparatus according to claim 1, wherein said particle release actuator comprises an electromechanical actuator arranged to deliver impact energy to said particle retainer.

30. Apparatus according to claim 29, wherein said electromechanical actuator comprises a solenoid.

31. Apparatus according to claim 1, further comprising an enclosure for covering at least said weight measuring device and said particle retainer.

58. A particle retainer intended for use in the apparatus of claim 1, said particle retainer comprising:

a hopper;

a sieve across the cross-section of the hopper.

59. A particle retainer according to claim 58, wherein said sieve is disposed at one end of said hopper.

60. A particle retainer according to claim 58, wherein said hopper is a glass tube and said sieve is an electro-formed mesh.

61. A particle retainer according to claim 58, wherein said hopper and said sieve are formed of one piece of plastics material.

62. A particle retainer according to claim 58, wherein said hopper and said sieve are formed of stainless steel.

63. A particle retainer according to claim 58, wherein said sieve has holes in the diameter range of 50-400 μ

m.

64. Processor intended for use as the processor in the apparatus of claim 2, said processor comprising:

signal output means for outputting an output signal of predetermined characteristic to a particle release actuator;

comparison means;

signal input means for supplying the value of an input signal derived from a signal output from a weight measuring device to said comparison means; and

memory means for feeding a predetermined weight value stored therein to said comparison means;

said comparison means being arranged to compare said input signal value to the predetermined weight value and to determine whether said input signal is greater than said predetermined weight value.

65. Processor according to claim 64, further comprising:

calculation means programmed and arranged to receive a signal from said weight measuring device and to add a correction value to this signal so as to calculate an estimate of the actual weight of dispensed particles, this estimate being fed to said signal input means.

66. Processor according to claim 65, wherein said calculation means calculates the rate of change of the signal received from said weight measuring device over time and uses this to obtain said correction value.

67. Processor according to claim 65, wherein said calculation means performs the following:

counting the number of times said particle release actuator is actuated within a defined time period;

determining a multiplication factor in accordance with the time during said defined time period that said particle release actuator is actuated;

multiplying a stored standard weight by said multiplication factor; and

adding said multiplied stored standard weight for each said actuation to obtain said correction value.

68. Processor according to claim 66, wherein said characteristic of said output signal is increased if said calculated rate of change is less than a predetermined desired value and decreased if said calculated rate of change is greater than said predetermined desired value.

69. Processor according to claim 64, further comprising:

sampling means for obtaining successive samples of said signal received from said weight measuring device;

second comparison means for comparing a plurality of said samples to determine whether a substantially stable level of said input signal has been reached when said stored value is not greater than said input signal.

71. A manufacturing station for manufacturing a particle cassette, comprising:

a collector for collecting an open and empty cassette;

a transporter for moving said open and empty cassette to a position at which its weight can be measured;

an apparatus in accordance with claim 1 for dispensing particles into said open cassette to obtain a loaded cassette.

72. A manufacturing station according to claim 71, further comprising:

a cassette closure station for closing a loaded cassette to contain therein the dispensed particles; and

a second transporter for moving a loaded cassette to said cassette closure station.

73. A manufacturing station according to claim 72, wherein said transporter for moving said open and empty cassette is the same transporter as said second transporter for moving said loaded cassette.

74. A manufacturing station according to claim 73, wherein said transporter for moving said cassette comprises a pivotally mounted arm, one end of said arm having a locator for locating said cassette.

75. A manufacturing station according to claim 73, wherein said transporter for moving said cassette comprises a rotatable circular component having a locator positioned on its circumference for locating said cassette.

76. A manufacturing station according to claim 74, wherein said locator is operable to grip and release said cassette.

77. A manufacturing station according to claim 71, further comprising:

an in-feed track for feeding in open and empty cassettes;

an out-feed track for feeding out loaded cassettes.

78. A production line, comprising:

a plurality of manufacturing stations having the construction of claim 71;

an in-feed track for feeding in open and empty cassettes; and

an out-feed track for feeding out closed and loaded cassettes;

wherein said plurality of respective transporters for moving said cassettes are operable to take open and empty cassettes from said in-feed track and to place closed and loaded cassettes onto said out-feed track.

79. A production line according to claim 78, further comprising:

a batch hopper movable between each particle retainer of each respective manufacturing station for refilling each said particle retainer with particles.

80. A particle dispensing station comprising:

a plurality of apparatuses according to claim 1; and

a batch hopper movable between each particle retainer of each respective apparatus for refilling each said particle retainer with particles.

82. An estimation function for use with the apparatus of claim 1 having the form:

W_R=W(t)+C

where W_R is the estimated actual weight, W(t) is the current apparent weight and C is a correction value, wherein C has the form;

$C=\underset{t=\mathrm{now}-t_p}{\overset{t=\mathrm{now}}{\sum <br><br>}}<br><br>M<br><br>\left(t\right)·<br><br>W_{\mathrm{ST}}$

where dW/dt(t) is the current apparent rate of change of weight with time, T is a time constant, now represents the present time, now-t_p represents a time t_p ago, M(t) is a multiplication factor and W_ST is a standard weight value.

4. Apparatus for dispensing particles, comprising:

a particle retainer for retaining a supply of the particles to be dispensed;

a particle release actuator for causing, in response to an actuation signal, some of said supply of particles to be dispensed from said particle retainer;

a weight measuring device for measuring the apparent weight of particles dispensed from said particle retainer and for outputting a signal representing the measured apparent weight; and

a processor operatively connected to said particle release actuator and arranged to output said actuation signal thereto and operatively connected to said weight measuring device and arranged to receive said measured apparent weight signal therefrom, said processor being arranged to estimate the actual weight of particles dispensed by adding a correction value to said measured apparent weight, said measured apparent weight signal being less than the actual weight.

5. Apparatus according to claim 4, further comprising a plurality of apertures through which said particles are dispensed.

32. A method of accurately dispensing particles, comprising the steps of:

retaining a supply of particles to be dispensed, said particles clogging a plurality of apertures;

vibrating said supply of particles to thereby cause said apertures to become unclogged so that some of said supply of particles is dispensed through said plurality of apertures from their retained position to a position where their weight can be measured;

measuring the apparent weight of said dispensed particles; and

utilizing said measured apparent weight to control particle dispensation.

33. A method according to claim 32, further comprising estimating the actual weight of particles dispensed by adding said measured apparent weight to a correction value to thereby reduce the effects of delays in obtaining a correct weight measurement.

36. A method according to claim 32, wherein said step of utilizing said measured apparent weight comprises determining if said measured apparent weight is equal to or greater than a predetermined weight of particles, and if not, cyclically repeating said method steps.

37. A method according to claim 33, wherein said step of utilizing said measured apparent weight comprises determining if said estimated actual weight is equal to or greater than a predetermined weight of particles, and if not, cyclically repeating said method steps.

38. A method according to claim 36 wherein said pre-determined weight comprises a desired weight of particles to be dispensed minus a tolerance weight.

39. A method according to claim 32, wherein said step of causing some of said supply of particles to be dispensed comprises actuating a particle release actuator.

40. A method according to claim 39, further comprising:

timing the period of time between successive actuations; and

calculating the apparent rate at which particles are dispensed to the weighing position.

41. A method according to claim 40, further comprising:

estimating the actual weight of particles dispensed by adding the measured apparent weight to the or a correction value based on said calculated apparent rate.

42. A method according to claim 41, wherein said correction value is obtained by multiplying said apparent rate by a time constant.

43. A method according to claim 39, wherein the or a correction value to be added to said measured apparent weight so as to estimate the actual weight of particles dispensed is calculated by:

counting the number of actuations within a defined time period; and

adding a stored standard weight to said correction value for each said actuation.

44. A method according to claim 43, further comprising:

multiplying each said stored standard weight by a multiplication factor of 1 or less, said multiplied standard weight being used instead of said standard weight when calculating said correction value.

45. A method according to claim 44, further comprising before said multiplying step:

determining said multiplication factor in accordance with the time during said defined time period that said actuation occurs.

46. A method according to claim 44, wherein said multiplication factor is determined using a function which generally linearly decreases for increased times since the corresponding actuation.

47. A method according to claims 43, further comprising:

updating said standard weight value.

48. A method according to claim 47, wherein said updating comprises:

obtaining a value for the average weight of particles dispensed as a result of each actuation made the last time the apparatus was used to dispense particles.

49. A method according to claim 48, wherein said value is obtained by:

dividing the total weight of dispensed particles by the number of actuations.

50. A method according to claim 41, further comprising:

comparing said estimated actual weight with a predetermined weight of particles so as to decide if further particle dispensation is required.

51. A method according to claim 50, wherein said predetermined weight of particles comprises a desired weight of particles to be dispensed minus a tolerance weight.

52. A method according to claim 40, further comprising:

determining if the calculated apparent rate during the previous cycle is less than a predetermined desired rate; and

if said calculated apparent rate is less than said predetermined desired rate causing more particles than were caused to be dispensed in the previous cycle to be dispensed in the current cycle.

53. A method according to claim 40, further comprising:

determining if the calculated apparent rate during the previous cycle is more than a predetermined desired rate; and

if said calculated apparent rate is more than said predetermined desired rate causing fewer particles than were caused to be dispensed in the previous cycle to be dispensed in the current cycle.

54. A method according to claim 40, further comprising:

determining if the calculated apparent rate during the previous cycle is more than a predetermined desired rate; and

if said calculated apparent rate is more than said predetermined desired rate pausing for a predetermined period of time.

55. A method according to claim 52, further comprising:

estimating the actual weight of particles dispensed by adding said measured apparent weight to a correction value to thereby reduce the effect of delays in obtaining a correct weight measurement;

determining whether one of said measured apparent weight and said estimated actual weight are within a predetermined range of a predetermined weight of particles;

if so, reducing said predetermined desired rate.

56. A method according to claim 39, wherein said step of actuating a particle release actuator comprises vibrating said supply of particles.

57. A method according to claim 32, wherein less than 5 mg of particles are dispensed.

70. A computer program for carrying out the method of claim 32.

34. A method of accurately dispensing particles, comprising the steps of:

retaining a supply of particles to be dispensed;

causing some of said supply of particles to be dispensed from their retained position to a position where their weight can be measured;

measuring the apparent weight of said dispensed particles;

estimating the actual weight of particles dispensed by adding said measured apparent weight to a positive correction value to thereby reduce the effects of delays in obtaining a correct weight measurement; and

utilizing said measured apparent weight to control particle dispensation.

35. A method according to claim 34, wherein each of said particles is dispensed through one of a plurality of apertures.

81. A method of estimating an actual weight of particles dispensed onto a weight measuring device having a non-instantaneous reaction time, the method comprising:

retaining particles to be dispensed;

actuating a particle release actuator to cause some of said particles to be dispensed to said weight measuring device;

obtaining a measured apparent weight; and

adding a correction value to said measured apparent weight, said correction value being derived by summing weighted amounts of a value representing the average weight dispensed in one actuation.