Technique for adjusting the locus of excitation of electrically excitable tissue

• US 6,988,006 B2
• Filed: 09/20/2002
• Issued: 01/17/2006
• Est. Priority Date: 04/04/1996
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: King, Gary W., Baudino, Michael D., Hrdlicka, Greg, Leinders, Rob
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US10/247,981
• Publication Number:
  US 20030018370A1
• Time in Patent Office: 1,215 Days
• Field of Search: 607/66, 607/68, 607/70, 607/72, 607/74, 607116-119, 607/46, 607/67, 607/148
• US Class Current: 607/70
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset

Abstract

The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

Claims

1. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism, comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue and forming an array of a first group of electrodes in an inner ring formation and a second group of electrodes in an outer ring formation;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide a potential to cause at least one of the outer ring of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first begin time and a first end time and the second pulse has a second begin time and a second end time, and wherein the generator is further configured to adjust a time delay between the first end time of the first pulse and the second begin time of the second pulse, wherein the time delay determines a size and location of a suprathreshold potential area.

2. The apparatus of claim 1, wherein the plurality of electrodes further comprises at least one electrode in a center of the inner ring formation.

3. The apparatus of claim 1, wherein the first and second pulses include pulse parameters, the pulse parameter selected from the group consisting of pulse width, pulse amplitude, pulse frequency, pulse rise time, pulse fall time, and pulse shape.

4. The apparatus of claim 1, wherein an increase of :

first pulse width results in an increase of the electric field.

5. The apparatus of claim 1, wherein an increase in :

first pulse width and a decrease in a second pulse width results in a shift of the electric field toward the second set of electrodes.

6. The apparatus of claim 1, wherein an increase in the time delay results in a decrease in the size of the suprathreshold potential area and in a shifting of the suprathreshold potential area toward the first set of electrodes.

7. The apparatus of claim 1, wherein the first and second sets of electrodes are cathodes and the return electrode is an anode, and wherein the return electrode is placed away from the first and second sets of electrodes such that potential on the return electrode does not perturb the electric field.

8. The apparatus of claim 7, wherein the apparatus further comprises in combination a metallic case, the metallic case holding the generator and serving as the return electrode.

9. The apparatus of claim 1, wherein the first and second pulses are simultaneous in time.

10. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism, comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue and forming an array of a first group of electrodes in an inner ring formation and a second group of electrodes in an outer ring formation;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode;

capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide a potential to cause at least one of the outer ring of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first weighted average time and the second pulse has a second weighted average time, wherein the generator is configured to adjust a time delay between the first and second weighted average times, wherein the time delay determines a size and location of a suprathreshold potential area.

11. The apparatus of claim 10, wherein the generator is further capable of increasing the time delay to thereby cause a decrease in the size of the suprathreshold potential area and a shift of the suprathreshold potential area toward the first set of electrodes.

12. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue and forming an array of a first group of electrodes in an inner ring formation and a second group of electrodes in an outer ring formation;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode;

capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide potential to cause at least one of the outer ring of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first peak time and the second pulse has a second peak time, wherein the generator is configured to adjust a time delay between the first and second peak times, wherein the time delay determines a size and location of a suprathreshold potential area.

13. The apparatus of claim 12, wherein the generator is further capable of increasing said time delay to thereby cause a decrease in the size of the suprathreshold potential area and a shift of the suprathreshold potential area toward the first set of electrodes.

14. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism, comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue, the plurality of electrodes comprising a first group of electrodes and a second group of electrodes, the second group of electrodes located at an outer position relative to the first group of electrodes;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode;

capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide a potential to cause at least one of the second group of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first begin time and a first end time and the second pulse has a second begin time and a second end time, and wherein the generator is further configured to adjust a time delay between the first end time of the first pulse and the second begin time of the second pulse, wherein the time delay determines a size and location of a suprathreshold potential area.

15. The apparatus of claim 14, wherein the first pulse and second pulse are current pulses.

16. The apparatus of claim 14, wherein the first pulse and the second pulse are voltage pulses.

17. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism, comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue, the plurality of electrodes comprising a first group of electrodes and a second group of electrodes, the second group of electrodes located at an outer position relative to the first group of electrodes;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode;

capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide a potential to cause at least one of the second group of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first weighted average time and the second pulse has a second weighted average time, wherein the generator is configured to adjust a time delay between the first and second weighted average times, wherein the time delay determines a size and location of a suprathreshold potential area.

18. The apparatus of claim 17, wherein the first pulse and second pulse are current pulses.

19. The apparatus of claim 17, wherein the first pulse and the second pulse are voltage pulses.

20. An apparatus for inducing action potentials at an adjustable locus of electrically excitable tissue of an organism, comprising in combination:

(A) at least one return electrode capable of being disposed within the organism;

(B) a plurality of electrodes adapted to be implanted adjacent to the tissue, the plurality of electrodes comprising a first group of electrodes and a second group of electrodes, the second group of electrodes located at an outer position relative to the first group of electrodes;

(C) a first set of at least one electrode of the first group of electrodes capable of being driven with a first pulse;

(D) a second set of at least one electrode of the second group of electrode;

capable of being driven with a second pulse;

(E) a generator configured to provide the first and second pulses to the first and second sets with respect to the return electrode to cause a steerable electric field, and to provide a potential to cause at least one of the second group of electrodes to become anodal thereby causing the electric field to be contained within a certain region and causing outer tissue to be shielded from activation; and

wherein the first pulse has a first peak time and the second pulse has a second peak time, wherein the generator is configured to adjust a time delay between the first and second peak times, wherein the time delay determines a size and location of a suprathreshold potential area.

21. The apparatus of claim 20, wherein the first pulse and second pulse are current pulses.

22. The apparatus of claim 20, wherein the first pulse and the second pulse are voltage pulses.