Administration of CPAP treatment pressure in presence of apnea

• US 6,988,498 B2
• Filed: 10/05/2004
• Issued: 01/24/2006
• Est. Priority Date: 11/07/1997
• Status: Expired due to Term

• Current Assignee: Resmed Limited (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Berthon-Jones, Michael, Farrugia, Steven Paul
• Primary Examiner(s): PATEL, MITAL B
• Application Number:
  US10/958,854
• Publication Number:
  US 20050076910A1
• Time in Patent Office: 476 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.22, 128/204.23
• US Class Current: 128/204.23
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0875 Connecting tubes
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase

Abstract

CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient'"'"'s airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, 62, 64) is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator (34, 38) to increase the treatment pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.

Claims

1. A method for the administration of CPAP treatment pressure comprising the steps of:

supplying breathable gas to a patient'"'"'s airway at an initial treatment pressure, and repeatedly;

determining a measure of respiratory airflow;

determining the occurrence of an apnea from a reduction in said measure of respiratory airflow below a threshold;

determining the duration of said apnea; and

increasing the treatment pressure by an amount which is an increasing function of the duration of said apnea, and a decreasing function of the treatment pressure immediately before said apnea.

2. CPAP treatment apparatus comprising:

a controllable flow generator operable to produce breathable gas at a pressure elevated above atmosphere;

a gas delivery tube coupled to the flow generator;

a patient mask coupled to the tube to receive said breathable gas from the generator and provide said gas, at a desired treatment pressure, to the patient'"'"'s airway;

a controller operable to receive input signals and to control operation of said flow generator and hence the treatment pressure; and

sensor means located at the flow generator, in the delivery tube or at the mask that generates a signal input to said controller from which patient respiratory airflow is determined;

and wherein said controller is operable to determine the occurrence of an apnea from a reduction in said respiratory airflow, determine the duration of said apnea, and cause said flow generator to increase CPAP treatment pressure by an increment that is an increasing function of said apnea duration and a decreasing function of the treatment pressure immediately prior to said apnea.

3. The CPAP treatment apparatus of claim 2, wherein there is a further determination of the occurrence of at least partial upper airway obstruction by the controller being further operable to detect the presence of characteristic changes in shape of an inspiratory flow versus time curve indicative of inspiratory airflow limitation.

4. A method for the administration of CPAP treatment pressure comprising the steps of:

supplying breathable gas to the patient'"'"'s airway at a treatment pressure;

determining a measure of respiratory airflow; and

determining the occurrence of an apnea from a reduction in the measure of respiratory airflow below a threshold, and, if having occurred,

(i) determining the duration of the apnea; and

(ii) increasing the treatment pressure by an amount which is an increasing function of the duration of the apnea, and a decreasing function of the treatment pressure immediately before the apnea.

5. The method of claim 4, wherein the increase in treatment pressure is substantially zero if the treatment pressure before the apnea exceeds a pressure threshold.

6. The method of claim 5, wherein the increase in pressure below the pressure threshold is an increasing function of the duration of the apnea, multiplied by the difference between the pressure threshold and the current treatment pressure.

7. The method of claim 6, wherein said increasing function of apnea duration is linear on apnea duration.

8. The method of claim 5, in which the pressure threshold is substantially 10 cm H2O.

9. The method of claim 4, wherein the occurrence of an apnea is determined by the steps of:

calculating the RMS respiratory airflow over a short time interval;

calculating the RMS respiratory airflow over a longer time interval; and

determining an apnea if the RMS respiratory airflow over the short time interval is less than a predetermined fraction of the RMS respiratory airflow over the longer time interval.

10. The method of claim 4, comprising the further step of reducing the treatment pressure towards an initial treatment pressure in the absence of a further apnea.

11. The method of claim 4, comprising the further steps of:

in the absence of an apnea, determining the presence of partial obstruction; and

if present, increasing the treatment pressure.

12. The method of claim 11, in which the presence of partial obstruction is determined from the shape of the patient'"'"'s inspiratory flow vs time curve.

13. The method of claim 11, in which the presence of partial obstruction is determined from the presence of snoring.

14. The method of claim 11, in which the presence of partial obstruction is determined from both the shape of the patient'"'"'s inspiratory flow vs time curve, and from the presence of snoring.

15. The method of claim 14, in which the patency of the airway is determined by the presence of a cardiogenic component in the respiratory airflow.

16. The method of claim 14, in which the patency of the airway is determined by the steps of:

modulating the treatment pressure at a known frequency;

measuring the component of the respiratory airflow at said modulation frequency;

calculating the conductance of the airway as the ratio of the amplitude of said component of the respiratory airflow to the amplitude of the mask pressure modulation; and

determining that the airway is patent if the conductance exceeds a conductance threshold.

17. The method of claim 4, comprising the further steps of:

if an apnea is occurring, determining whether the patient'"'"'s airway is patent during the apnea; and

if the airway is patent, setting the increase in treatment pressure to zero.