Therapeutic treatments using the direct application of antimicrobial metal compositions

• US 6,989,156 B2
• Filed: 04/23/2002
• Issued: 01/24/2006
• Est. Priority Date: 04/23/2001
• Status: Expired due to Fees

• Current Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Original Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Inventors: Gillis, Scott H.
• Primary Examiner(s): PAK, JOHN D
• Application Number:
  US10/128,208
• Publication Number:
  US 20030086977A1
• Time in Patent Office: 1,372 Days
• Field of Search: 424/400, 424/402, 424/404, 424/405, 424/489, 424/490, 424/600, 424/604, 424617-619, 424630-635, 424637-638, 424641-643, 424/646, 424649-651, 424/653, 514492-495, 514499-500, 514/503, 514/825, 514/886, 514/951, 514/964
• US Class Current: 424/618
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/12 Powders or granules A01N25/26 takes precedence
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/242 Gold; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/0078 for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/102 : Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 : Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 : Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/452 : Lubricants
• CPC Class Codes: A61L 2300/606 : Coatings
• CPC Class Codes: A61L 2300/624 : Nanocapsules
• CPC Class Codes: A61L 2300/63 : Crystals
• CPC Class Codes: A61L 27/30 : Inorganic materials
• CPC Class Codes: A61L 29/10 : Inorganic materials
• CPC Class Codes: A61L 31/082 : Inorganic materials
• CPC Class Codes: A61P 1/00 : Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 : Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 11/00 : Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 : Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/04 : for throat disorders
• CPC Class Codes: A61P 13/00 : Drugs for disorders of the urinary system
• CPC Class Codes: A61P 13/08 : of the prostate
• CPC Class Codes: A61P 15/00 : Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 : Antipruritics
• CPC Class Codes: A61P 17/06 : Antipsoriatics
• CPC Class Codes: A61P 17/08 : Antiseborrheics
• CPC Class Codes: A61P 17/10 : Anti-acne agents
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 : for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 27/16 : Otologicals
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: Y10S 424/15 : Suppositories
• CPC Class Codes: Y10T 428/31855 : Of addition polymer from unsaturated monomers

Abstract

Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.

Claims

1. A method for treating tissue, comprising:

forming a solution at a site remote from the tissue which is to be treated by dissolving in water at least one antimicrobial metal with atomic disorder; and

applying the solution in therapeutically effective amount to the tissue which is to be treated,

wherein the tissue comprises at least one tissue selected from the group consisting of endocardium tissue, pericardium tissue, bone tissue, and joint tissue, and the at least one antimicrobial metal with atomic disorder has sufficient atomic disorder so that, when in contact with an alcohol or water-based electrolyte, said at least one antimicrobial metal with atomic disorder releases atoms, ions, molecules, or clusters of the at least one antimicrobial metal into the alcohol or water-based electrolyte on a sustainable basis.

2. A method according to claim 1 wherein the at least one antimicrobial metal is in nanocrystalline form.

3. A method according to claim 2 wherein the at least one antimicrobial metal is nanocrystalline silver.

4. A method according to claim 1 wherein the solution is applied by passing it through a catheter to the tissue which is to be treated.

5. A method according to claim 1 wherein the solution is applied by injection into the tissue which is to be treated.

6. A method according to claim 5 wherein injection is effected by the use of a needle.

7. A method according to claim 5 wherein injection is needle-less injection.

8. A method according to claim 1 wherein the solution is applied by injection into a body cavity so as to contact the tissue which is to be treated.

9. A method for treating tissue, comprising:

forming a solution at a site remote from the tissue which is to be treated by dissolving in water at least one noble metal with atomic disorder; and

applying the solution in therapeutically effective amount to the tissue which is to be treated,

wherein the tissue comprises at least one tissue selected from the group consisting of endocardium tissue, pericardium tissue, bone tissue, and joint tissue, and the at least one noble metal with atomic disorder has sufficient atomic disorder so that, when in contact with an alcohol or water-based electrolyte, said at least one noble metal with atomic disorder releases atoms, ions, molecules, or dusters of the at least one noble metal into the alcohol or water-based electrolyte on a sustainable basis.

10. A method according to claim 9, wherein the at least one noble metal is in nanocrystalline form.

11. A method according to claim 10, wherein the at least one noble metal is nanocrystalline silver.

12. A method according to claim 9, wherein the solution is applied by passing it through a catheter to the tissue which is to be treated.

13. A method according to claim 9, wherein the solution is applied by injection into the tissue which is to be treated.

14. A method according to claim 13, wherein injection is effected by the use of a needle.

15. A method according to claim 13, wherein injection is needle-less injection.

16. A method according to claim 9, wherein the solution is applied by injection into a body cavity so as to contact the tissue which is to be treated.