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Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues

  • US 6,989,528 B2
  • Filed: 06/04/2004
  • Issued: 01/24/2006
  • Est. Priority Date: 06/06/2003
  • Status: Active Grant
First Claim
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1. An analytical instrument for the characterization and analysis of a sample comprising:

  • a MALDI sampling device to desorb at least a portion of said sample, said MALDI sampling device comprising a sample stage, said sample stage capable of accommodating a sample;

    a component selected from the group consisting of an inorganic cluster ion beam source, a vapor deposition system, a laser ablation deposition system, a desorption deposition source, and any combination thereof, said component being capable of adding a matrix to said sample, said component being fluidly coupled to said MALDI sampling device;

    a laser coupled to said MALDI sampling device, said laser being capable of desorbing material from said sample;

    an ion mobility cell having a drift tube, said mobility cell coupled to said MALDI sampling device and capable of receiving sample from said MALDI sampling device; and

    ,a time-of-flight mass spectrometer having a flight tube positioned orthogonally to said drift tube, said flight tube fluidly coupled to said drift tube.

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