Apparatus for measurement of blood analytes
First Claim
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1. An apparatus for measuring hemoglobin index (HbI) in blood of a patient, comprising:
- a light source generating broadband light;
a light-transmission arrangement including a plurality of transmitting fibers positioned for simultaneously transmitting multiple wavelengths of said broadband light from said light source to the blood of the patient;
an optical fiber arrangement having a plurality of light detector fibers for leading multi-wavelength light, in spectrally unseparated form, transmitted through, or reflected from, the blood;
a light detection arrangement receiving said multi-wavelength light in its spectrally unseparated form from said optical fiber arrangement, for spectrally decomposing the received light, and for determining amplitudes of selected wavelengths of the decomposed light; and
, means for utilizing a non-pulsatile element of the blood of the patient for determining a measurement of the hemoglobin index (HbI) in the blood as a function of the amplitudes of the selected wavelengths.
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Abstract
There is described a device for the non-invasive measurement of one or more analytes in blood in a patient'"'"'s body part which comprises a light transmitter comprising a plurality of transmitting fibres positioned to transmit light to the body part and a light detector comprising a plurality of light detector fibres position to detect light transmitted through or reflected from the body part. The device especially utilises the non-pulsatile element of a patient'"'"'s blood. There is also described a method of measuring blood glucose levels and a device programmed so as to calculate one or more of the haemoglobin index, the oxygen index and the blood oxygen saturation.
211 Citations
23 Claims
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1. An apparatus for measuring hemoglobin index (HbI) in blood of a patient, comprising:
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a light source generating broadband light;
a light-transmission arrangement including a plurality of transmitting fibers positioned for simultaneously transmitting multiple wavelengths of said broadband light from said light source to the blood of the patient;
an optical fiber arrangement having a plurality of light detector fibers for leading multi-wavelength light, in spectrally unseparated form, transmitted through, or reflected from, the blood;
a light detection arrangement receiving said multi-wavelength light in its spectrally unseparated form from said optical fiber arrangement, for spectrally decomposing the received light, and for determining amplitudes of selected wavelengths of the decomposed light; and
,means for utilizing a non-pulsatile element of the blood of the patient for determining a measurement of the hemoglobin index (HbI) in the blood as a function of the amplitudes of the selected wavelengths. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for measuring blood oxygen saturation in blood of a patient, comprising the steps of:
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placing against a body part of a patient an apparatus for a non-invasive measurement of at least one analyte in blood in a body part of a patient, said apparatus comprising;
a light transmitter having a plurality of transmitting fibers positioned for transmitting light to the body part of the patient;
a light detector having a plurality of light detector fibers for detecting light transmitted through, or reflected from, the body part of the patient;
means for utilizing a non-pulsatile element of the blood in the body part of the patient for determining a measurement of at least one analyte in the blood; and
,means for measuring blood oxygen saturation (SO2), said means for measuring blood oxygen saturation (SO2) including calculation means using the equation;
SO2=100·
(OXI+0.43)/1.5wherein, OXI is the oxygenation index of the blood of the patient and is defined by the equation;
OXI=(e−
d)/11.7−
(d−
c)/11.6)·
100/HbI,wherein, HbI is the hemoglobin index of the blood of the patient and is defined by the equation;
HbI=((b−
a)/27.1+(c−
b)/21.4+(c−
e)/23.3+(c−
f)/13.6)·
100,and wherein, a=absorption value at 500.9 nm wavelength of light;
b=absorption value at 528.1 nm wavelength of light;
c=absorption value at 549.5 nm wavelength of light;
d=absorption value of 561.1 nm wavelength of light;
e=absorption value of 572.7 nm wavelength of light; and
,f=absorption value of 586.3 nm wavelength of light;
and, utilizing said light detector of said apparatus for measuring light transmitted through, or reflected from, the body part of the patient.
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21. A computer program for measuring one or more of the hemoglobin index, the oxygenation index or the blood oxygen saturation level in blood of a patient, comprising:
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a computer readable medium having computer program code means on said computer readable medium, said computer program code means calculating one or more of the following equations;
HbI is the hemoglobin index of the blood of the patient and is defined by the equation;
HbI=((b−
a)/27.1+(c−
b)/21.4+(c−
e)/23.3+(c−
f)/13.6)·
100,wherein, a=absorption value at 500.9 nm wavelength of light;
b=absorption value at 528.1 nm wavelength of light;
c=absorption value at 549.5 nm wavelength of light;
d=absorption value of 561.1 nm wavelength of light;
e=absorption value of 572.7 nm wavelength of light; and
,f=absorption value of 586.3 nm wavelength of light;
OXI is the oxygenation index of the blood of the patient and is defined by the equation;
OXI=[(e−
d)/11.7−
(d−
c)/11.6]·
100/HbI; and
,SO2 is the blood oxygen saturation of the blood of the patient and is defined by the equation;
SO2=100·
(OXI+0.43)/1.5.
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22. An apparatus for a non-invasive measurement of at least one analyte in blood in a body part of a patient, comprising:
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a light transmitter having a plurality of transmitting fibers positioned for transmitting light to the body part of the patient;
a light detector having a plurality of light detector fibers for detecting light transmitted through, or reflected from, the body part of the patient; and
,means for utilizing a non-pulsatile element of the blood in the body part of the patient for determining a measurement of at least one analyte in the blood, said measurement of said at least one analyte including means for measuring blood oxygen saturation (SO2) using the equation;
SO2=100·
(OXI+0.43)/1.5,wherein, OXI is the oxygenation index of the blood of the patient and is defined by the equation;
OXI=[(e−
d)/11.7−
(d−
c)/11.6]·
100/HbI,wherein, HbI is the hemoglobin index of the blood of the patient and is defined by the equation;
HbI=[(b−
a)/27.1+(c−
b)/21.4+(c−
e)/23.3+(c−
f)/13.6]·
100,wherein, a=absorption value at 500.9 nm wavelength of light;
b=absorption value at 528.1 nm wavelength of light;
c=absorption value at 549.5 nm wavelength of light;
d=absorption value of 561.1 nm wavelength of light;
e=absorption value of 572.7 nm wavelength of light; and
,f=absorption value of 586.3 nm wavelength of light.
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23. An apparatus for a non-invasive measurement of at least one analyte in blood in a body part of a patient, comprising:
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a light transmitter having a plurality of transmitting fibers positioned for transmitting light to the body part of the patient;
a light detector having a plurality of light detector fibers for detected light transmitted through, or reflected from, the body part of the patient; and
,means for utilizing a non-pulsatile element of the blood in the body part of the patient for determining a measurement of at least one analyte in the blood, said measurement of said at least one analyte including means for measuring the hemoglobin index (HbI) includes calculation means using the equation;
HbI=[(b−
a)/27.1+(c−
b)/21.4+(c−
e)/23.3+(c−
f)/13.6]·
100,wherein, a=absorption value at 500.9 nm wavelength of light;
b=absorption value at 528.1 nm wavelength of light;
c=absorption value at 549.5 nm wavelength of light;
d=absorption value of 561.1 nm wavelength of light;
e=absorption value of 572.7 nm wavelength of light; and
,f=absorption value of 586.3 nm wavelength of light.
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Specification
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Current AssigneeWhitland Research Ltd. (Edwards Lifesciences Corporation)
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Original AssigneeEdwards Lifesciences (Edwards Lifesciences Corporation)
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InventorsParker, Dawood, Harrison, David Keith
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Primary Examiner(s)WINAKUR, ERIC FRANK
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Assistant Examiner(s)Kremer, Matthew
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Application NumberUS09/743,206Time in Patent Office2,398 DaysField of Search600322-323, 600/326, 600/316, 600/349, 600/328, 600/344US Class Current600/328CPC Class CodesA61B 5/14532 for measuring glucose, e.g....A61B 5/1455 using optical sensors, e.g....A61B 5/14551 for measuring blood gasesB65H 23/18 by controlling or regulatin...
