Percutaneous biological fluid sampling and analyte measurement devices and methods
First Claim
1. A method for testing a biological fluid within the skin of a patient and for determining the concentration of a target constituent contained therein, the method comprising the steps of:
- providing an electrochemical cell comprising concentrically spaced-apart inner and outer electrodes and a reaction chamber therebetween, wherein the positions of the inner and outer electrodes are fixed relative to each other, the outer electrode comprising a blunt distal end and the inner electrode comprising a distal end configured to pierce the skin;
inserting the distal end of the inner electrode into the skin;
contacting the skin and exerting a pressure thereon with the blunt distal end of the outer electrode; and
transferring a sample of biological fluid from the pierced skin into the reaction chamber.
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Accused Products
Abstract
A device for sampling a biological fluid and measuring at least one target constituent within the biological fluid. The device has at least one electrochemical cell having an inner electrode and an outer electrode in a concentrically-spaced relationship. In a preferred embodiment, the outer electrode has a cylindrical configuration having an open distal end and the inner electrode has an elongated configuration positioned co-axially within the outer electrode and a distal end configured to penetrate the skin. The spacing between the electrodes exerts a capillary force on biological fluid present at the open distal end of the outer electrode. A system is also provided which includes a control unit in electrical communication with the electrochemical cell for controlling the selection and measurement of the target constituent. Methods of sampling of biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive devices and/or systems.
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Citations
10 Claims
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1. A method for testing a biological fluid within the skin of a patient and for determining the concentration of a target constituent contained therein, the method comprising the steps of:
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providing an electrochemical cell comprising concentrically spaced-apart inner and outer electrodes and a reaction chamber therebetween, wherein the positions of the inner and outer electrodes are fixed relative to each other, the outer electrode comprising a blunt distal end and the inner electrode comprising a distal end configured to pierce the skin;
inserting the distal end of the inner electrode into the skin;
contacting the skin and exerting a pressure thereon with the blunt distal end of the outer electrode; and
transferring a sample of biological fluid from the pierced skin into the reaction chamber. - View Dependent Claims (2, 3, 4)
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5. An electrochemical cell for use in sampling biological fluid and measuring an analyte therein, the cell comprising:
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a first electrode comprising a continuous wall configuration having a distal edge defining a pressure ring;
a second electrode comprising an elongated configuration having a length that extends concentrically within the first electrode, wherein the positions of the first and second electrodes are fixed relative to each other, the second electrode having a distal end configured to pierce a skin surface; and
an open space between the distal edge of the first electrode and the distal end of the second electrode. - View Dependent Claims (6, 7, 8, 9, 10)
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Specification