Programmable signal analysis device for detecting neurological signals in an implantable device

• US 6,990,372 B2
• Filed: 04/11/2002
• Issued: 01/24/2006
• Est. Priority Date: 04/11/2002
• Status: Active Grant

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Schulman, Joseph H., Mandell, Lee J., Perron, Christian Y.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US10/121,881
• Publication Number:
  US 20030195578A1
• Time in Patent Office: 1,384 Days
• Field of Search: 600/302, 600/509, 600/301, 600/513, 600/519, 600/521, 600544-546, 128/901, 128/902, 128/920
• US Class Current: 600/544
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient

Abstract

A programmable signal analysis device for detecting and counting neurological and muscular events in living tissue that incorporates one or more signal threshold levels to identify an event, a counter to count events, and a timer to determine event frequency as events per unit time. The threshold levels and counter/timer operating modes/parameters are digitally programmable to identify and count events, i.e., electrical signals having defined parameters. Such a circuit is of particular use in a microstimulator/sensor which is capable of being injected into living tissue at the site of interest. The microstimulator/sensor is used to stimulate a neural pathway or muscle and/or to block a neural pathway to alleviate pain or block stimulation of a muscle.

Claims

1. A signal analysis device for use within an implantable device, wherein said implantable device is configured at least in art for sensing a biological signal within a patient'"'"'s body, said signal analysis device comprising:

a sealed elongate housing having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm;

sensing circuitry contained within said sealed elongate housing for receiving a biological signal within said implantable device and generating a sensed voltage output in response thereto;

event detection circuit contained within said sealed elongate housing for detecting an attribute of said sensed output according to one or more designated criteria and designating said detected attribute as an event, wherein said event detection circuit is alternatively configurable for determining whether an event occurred according to one or according to two or more programmable criteria;

an event counter contained within said sealed elongate housing configured for accumulating detected events;

a clock counter contained within said sealed elongate housing for accumulating clock pulses;

event analysis circuitry contained within said sealed elongate housing for determining a processed value corresponding to said detected events and said accumulated clock pulses; and

wherein

said programmable criteria include at least first and second threshold levels and is further alternatively configurable to determine an event when;

said sensed voltage output increases above said first threshold level and then decreases below said first threshold level;

or

said sensed voltage output increases above said first threshold level and then decreases below said first threshold level without exceeding said second threshold level.

2. The signal analysis device of claim 1 wherein said signal analysis device additionally comprises:

an average peak detector contained within said sealed elongate housing for determining an average peak value of voltage peaks of said sensed voltage output; and

wherein

said first and second threshold levels are effectively adjusted according to changes in said average peak value.

3. The signal analysis device of claim 1 additionally comprising:

a peak detector contained within said sealed elongate housing for determining peaks of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events.

4. The signal analysis device of claim 1 wherein said programmable criteria includes at least first and second threshold levels and wherein said signal analysis device additionally comprises:

a peak detector contained within said sealed elongate housing for determining peaks of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events when said peaks correspond to voltages that are greater than said first threshold level and less than said second threshold level.

5. The signal analysis device of claim 1 wherein said event detection circuitry comprises:

first and second digital to analog converters for receiving digital values corresponding to first and second programmable threshold levels and generating first and second analog threshold levels in response thereto;

first and second comparators for comparing said first and second analog threshold levels to said sensed voltage output; and

programmable criteria logic for receiving outputs from said first and second comparators and determining events according to programmable criteria.

6. The signal analysis device of claim 1 wherein said event detection circuitry comprises:

an analog to digital converter for receiving said sensed voltage output and periodically converting said sensed voltage output value to a digital sensed voltage value; and

programmable criteria logic for receiving said digital sensed voltage value and determining events according to programmable criteria related to said digital sensed voltage value.

7. The signal analysis device of claim 6 wherein said programmable criteria logic comprises a digital signal processor.

8. The signal analysis device of claim 1 wherein said event detection circuitry comprises a digital signal processor for receiving said sensed voltage output, periodically converting said sensed voltage output to a digital sensed voltage value, and determining events according to programmable criteria related to said digital sensed voltage value.

9. The signal analysis device of claim 8 wherein said digital signal processor additionally includes said event analysis circuitry.

10. The signal analysis device of claim 1 wherein said event detection circuitry determines an average peak value of voltage peaks of said sensed voltage output;

and wherein

said first and second threshold levels are effectively adjusted according to changes in said average peak value.

11. A signal analysis device for use within an implantable device, wherein said implantable device is configured at least in art for sensing a biological signal within a patient'"'"'s body, said signal analysis device comprising:

a sealed elongate housing having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm;

sensing circuitry contained within said sealed elongate housing for receiving a biological signal within said implantable device and generating a sensed voltage output in response thereto;

event detection circuitry contained within said sealed elongate housing that is alternatively configurable to determine whether an event occurred according to one or according to two or more programmable criteria for detecting an attribute of said sensed voltage output and designating said detected attribute as an event;

an event counter contained within said sealed elongate housing configured for accumulating detected events;

a clock counter contained within said sealed elongate housing for accumulating clock pulses;

event analysis circuitry contained within said sealed elongate housing configurable for operation in a plurality of modes of operation for determining a processed value corresponding to said detected events and said accumulated clock pulses; and

wherein

said programmable criteria include at least first and second threshold levels and is further alternatively configurable to determine an event when;

said sensed voltage output increases above said first threshold level and then decreases below said first threshold level;

or

said sensed voltage output increases above said first threshold level and then decreases below said first threshold level without exceeding said second threshold level.

12. The signal analysis device of claim 11 wherein said signal analysis device additionally comprises:

an average peak detector contained within said sealed elongate housing for determining an average peak value of voltage peaks of said sensed voltage output; and

wherein

said first and second threshold levels are effectively adjusted according to changes in said average peak value.

13. The signal analysis device of claim 11 additionally comprising:

a peak detector contained within said sealed elongate housing for determining peaks of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events.

14. The signal analysis device of claim 11 wherein said programmable criteria includes at least first and second threshold levels and wherein said signal analysis device additionally comprises:

a peak detector contained within said sealed elongate housing for determining peaks of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events when said peaks correspond to voltages that are greater than said first threshold level and less than said second threshold level.

15. The signal analysis device of claim 11 wherein said event detection circuitry comprises:

first and second digital to analog converters for receiving digital values corresponding to first and second programmable threshold levels and generating first and second analog threshold levels in response thereto;

first and second comparators for comparing said first and second analog threshold levels to said sensed voltage output; and

programmable criteria logic for receiving outputs from said first and second comparators and determining events according to programmable criteria.

16. The signal analysis device of claim 11 wherein said event detection circuitry comprises:

an analog to digital converter for receiving said sensed voltage output and periodically converting said sensed voltage output value to a digital sensed voltage value; and

programmable criteria logic for receiving said digital sensed voltage value and determining events according to programmable criteria.

17. The signal analysis device of claim 11 wherein said programmable criteria logic comprises a digital signal processor.

18. The signal analysis device of claim 11 wherein said event detection circuitry comprises a digital signal processor for receiving said sensed voltage output, periodically converting said analog sensed voltage output to a digital sensed voltage value, and determining events according to programmable criteria related to said digital sensed voltage value.

19. The signal analysis device of claim 18 wherein said digital signal processor additionally includes said event analysis circuitry.

20. The signal analysis device of claim 11 wherein said event detection circuitry determines an average peak value of voltage peaks of said sensed voltage output;

and wherein

said first and second threshold levels are effectively adjusted according to changes in said average peak value.

21. A signal analysis device for use within an implantable device, wherein said implantable device is configured at least in part for sensing a biological signal within a patient'"'"'s body, said signal analysis device comprising:

a sealed elongate housing having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm;

sensing circuit contained within said sealed elongate housing for receiving a biological signal within said implantable device and generating a sensed voltage output in response thereto;

event detection circuitry contained within said sealed elongate housing for detecting an attribute of said sensed output according to one or more designated criteria and designating said detected attribute as an event;

an event counter contained within said sealed elongate housing configured for accumulating detected events;

a clock counter contained within said sealed elongate housing for accumulating clock pulses;

event analysis circuitry contained within said sealed elongate housing for determining a processed value corresponding to said detected events and said accumulated clock pulses; and

wherein

said event detection circuitry determines peak values of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events when said peaks correspond to voltages that are greater than a first threshold level and less than a second threshold level.

22. A signal analysis device for use within an implantable device, wherein said implantable device is configured at least in art for sensing a biological signal within a patient'"'"'s body, said signal analysis device comprising:

a sealed elongate housing having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm;

sensing circuitry contained within said sealed elongate housing for receiving a biological signal within said implantable device and generating a sensed output in response thereto;

event detection circuitry contained within said sealed elongate housing that is alternatively configurable to determine whether an event occurred according to one or according to two or more programmable criteria for detecting an attribute of said sensed voltage output and designating said detected attribute as an event;

an event counter contained within said sealed elongate housing configured for accumulating detected events;

a clock counter contained within said sealed elongate housing for accumulating clock pulses;

event analysis circuitry contained within said sealed elongate housing configurable for operation in a plurality of modes of operation for determining a processed value corresponding to said detected events and said accumulated clock pulses; and

wherein

said event detection circuitry determines peak values of said sensed voltage output; and

wherein

said event detection circuitry designates said peaks as events when said peaks correspond to voltages that are greater than a first threshold level and less than a second threshold level.