Adjustment of the breakpoint of the rate response curve based on minute ventilation values

• US 6,990,375 B2
• Filed: 03/01/2002
• Issued: 01/24/2006
• Est. Priority Date: 03/02/2001
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kadhiresan, Veerichetty, Auricchio, Angelo, Kloss, Michael
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US10/087,222
• Publication Number:
  US 20020151936A1
• Time in Patent Office: 1,425 Days
• Field of Search: 607/4, 607/9, 607 17- 20
• US Class Current: 607/20
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A method and system for operating a rate-adaptive pacemaker utilizing minute ventilation to measure exertion level. The method is applicable to heart failure patients who exhibit an oscillatory minute ventilation pattern.

Claims

1. A method for adjusting the responsiveness of a rate-adaptive pacemaker operating in a patient, wherein measured minute ventilation values in the patient are mapped to a pacing rate by a dual-slope rate response curve, comprising:

measuring minute ventilation values and determining that an average of those minute ventilation values are increasing, signifying that the patient'"'"'s exertion level is increasing;

determining an amplitude of an oscillatory component in the measured minute ventilation values to be above a specified threshold value; and

,

if the amplitude of the oscillatory component falls below the specified threshold value as the average minute ventilation continues to increase, setting the breakpoint of the rate response curve equal to the presently measured minute ventilation value.

2. The method of claim 1 wherein the measured minute ventilation values are passed through a high pass filter to determine the oscillatory component.

3. The method of claim 2 wherein the oscillatory component is in an approximate frequency range between 0.01 and 0.05 Hz.

4. The method of claim 1 further comprising:

measuring an activity level of the patient;

if the amplitude of the oscillatory component is below the specified threshold value, adjusting the pacing rate in accordance with the measured minute ventilation value and rate-response curve; and

,

if the amplitude of the oscillatory component is above the specified threshold, cross-checking the measured minute ventilation value with a measured activity level before adjusting the pacing rate.

5. The method of claim 1 further comprising pacing one or both ventricles in a ventricular resynchronization pacing mode.

6. The method of claim 5 further comprising transmitting an indication of the amplitude of the oscillatory component to an external programmer.

7. The method of claim 5 further comprising adjusting an operating parameter of the pacemaker if the amplitude of the oscillatory component in the measured minute ventilation values is above a specified threshold value.

8. The method of claim 7 wherein the adjusted operating parameter is an atrio-ventricular interval.

9. The method of claim 7 wherein the adjusted operating parameter is a biventricular offset interval.

10. A rate-adaptive pacemaker, comprising;

sensing and pacing channels for sensing cardiac depolarizations and delivering paces to a selected chamber;

a minute ventilation sensor,

a controller for controlling the delivery of paces in accordance with a pacing mode at a programmed pacing rate, wherein measured minute ventilation values in the patient are mapped to a pacing rate by a dual-slope rate response curve;

wherein the controller is configured to determine if an amplitude of an oscillatory component in the measured minute ventilation values is above a specified threshold value and, if the amplitude of the oscillatory component falls below the specified threshold value as an average minute ventilation continues to increase, to set the breakpoint of the rate response curve equal to the presently measured minute ventilation value.

11. The pacemaker of claim 10 further comprising a bandpass filter for extracting the oscillatory component from the measured minute ventilation values.

12. The pacemaker of claim 10 wherein the filter has a passband in an approximate frequency range between 0.01 and 0.05 Hz.

13. The pacemaker of claim 10 wherein the controller is further programmed to adjust the pacing rate in accordance with the measured minute ventilation value and rate-response curve if the amplitude of the oscillatory component is below the specified threshold value, and,

if the amplitude of the oscillatory component is above the specified threshold, to cross-check the measured minute ventilation value with a measured activity level before adjusting the pacing rate.

14. The pacemaker of claim 10 wherein the controller is programmed to pace one or both ventricles in a ventricular resynchronization pacing mode.

15. The pacemaker of claim 14 further comprising a telemetry interface for transmitting an indication of the amplitude of the oscillatory component to an external programmer.

16. The pacemaker of claim 14 wherein the controller is configured to adjust an operating parameter of the pacemaker if the amplitude of the oscillatory component in the measured minute ventilation values is above a specified threshold value.

17. The pacemaker of claim 16 wherein the operating parameter adjusted by the controller is an atrio-ventricular interval.

18. The pacemaker of claim 16 wherein the operating parameter adjusted by the controller is a biventricular offset interval.

19. The pacemaker of claim 16 wherein the operating parameter adjusted by the controller is a pacing configuration that determines which pacing channels are to be used for pacing.

20. The pacemaker of claim 16 wherein the operating parameter adjusted by the controller is a rate-adaptive pacing parameter.