Methods and systems for selective control of bladder function

• US 6,990,376 B2
• Filed: 12/06/2002
• Issued: 01/24/2006
• Est. Priority Date: 12/06/2002
• Status: Expired due to Fees

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Tanagho, Emil A., Gleason, Curtis A.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US10/313,960
• Publication Number:
  US 20040111126A1
• Time in Patent Office: 1,145 Days
• Field of Search: 607/40, 607/41, 607/2, 607/46, 607/48, 607/70, 607/72, 607/74
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain

Abstract

A method and system for selective inhibition of somatic nerve fibers in a mixed nerve containing both somatic and autonomic nerve fibers where the method finds use in treatment of chronic pain, spastic muscles and for sensory and motor control of a bladder. The methods and systems utilize alternate phase rectangular electrical pulses. An electrical pulse generator is coupled to a nerve. An alternate phase high frequency, low amplitude pulse is first applied to selectively inhibit somatic nerves when present in a mixed nerve. An alternate phase low frequency, high amplitude phase pulse subsequently supplied to stimulate the autonomic nerve fibers and in the case of the sacral root will permit a controlled voiding of the bladder and bowel.

Claims

1. A method of controlling a bladder or a bowel, said method comprising:

applying alternate phase high frequency, low amplitude pulse pairs to a nerve that innervates said bowel or bladder; and

applying alternate phase low frequency, high amplitude pulse pairs to said nerve to void the bladder or bowel, while continuing to apply the alternate phase high frequency, low amplitude pulse pairs.

2. The method of claim 1, wherein the high frequency pulse pairs are at least 50 pulse pairs per second.

3. The method of claim 1, wherein the high frequency pulse pairs range from about 50 to about 200 pulse pairs per second.

4. The method of claim 3 , wherein the high frequency pulse pairs range from about 80 to about 120 pulse pairs per second.

5. The method of claim 1, wherein the low frequency pulse pairs are in a range of up to about 40 pulse pairs per second.

6. The method of claim 5, wherein the low frequency pairs are in a range of about 15 to about 25 pulse pairs per second.

7. The method of claim 1, wherein the amplitude of high frequency pulse pairs ranges from about 0.1 milliamperes to about 1.5 milliamperes.

8. The method of claim 1, wherein the amplitude of high frequency pulse pairs ranges from about 0.3 milliamperes to about 0.8 milliamperes.

9. The method of claim 1, wherein the amplitude of low frequency pulse pairs ranges from about 1 milliamperes to about 3 milliamperes.

10. The method of claim 9, wherein the amplitude of low frequency pulse pairs ranges from about 1.3 milliamperes to about 1.7 milliamperes.

11. The method of claim 1, wherein the high frequency pulses have pulse widths in a range of about 0.01 ms to about 0.5 ms.

12. The method of claim 11, wherein the high frequency pulses have pulse widths in a range of about 0.08 ms to about 0.12 ms.

13. The method of claim 1, wherein the low frequency pulses have pulse widths in a range of about 0.1 ms to about 1.0 ms.

14. The method of claim 13, wherein the low frequency pulses have pulse widths of approximately 0.5 ms.

15. A system for controlling a bladder or bowel, said system comprising:

an electrical pulse generator configured to produce alternate phase high frequency, low amplitude pulses and an alternate phase low frequency, high amplitude pulses to a sacral nerve;

at least one electrode that can be coupled to a nerve and transmit an electrical signal from said pulse generator to said nerve; and

an external power source electromagnetically coupled to the electrical pulse generator.

16. The system of claim 15, wherein said electrode is coupled to the sacral nerve and in electrical communication with the electrical pulse generator.

17. The system of claim 15, wherein the system comprises two electrodes coupled to the electrical pulse generator with four wires.

18. The system of claim 15, further comprising a pressure sensitive switch on the electrical pulse generator.

19. A method of controlling a bladder or a bowel, the method comprising:

providing an electrical pulse generator;

operatively linking the electrical pulse generator to at least one nerve;

applying alternate phase high frequency, low amplitude pulse pairs to the nerve; and

applying low frequency, high amplitude pulse pairs to the nerve to void the bladder while continuing to apply the alternate phase high frequency, low amplitude pulse pairs.

20. The method of claim 19, wherein the high frequency pulse pairs are at least 50 pulse pairs per second.

21. The method of claim 19, wherein the high frequency pulse pairs range from about 50 to about 200 pulse pairs per second.

22. The method of claim 21, wherein the high frequency pulse pairs range from about 80 to about 120 pulse pairs per second.

23. The method of claim 19, wherein the low frequency pulse pairs are in a range of up to about 40 pulse pairs per second.

24. The method of claim 23, wherein the low frequency pairs are in a range of about 15 to about 25 pulse pairs per second.

25. The method of claim 19, wherein the amplitude of high frequency pulse pairs ranges from about 0.1 milliamperes to about 1.5 milliamperes.

26. The method of claim 25, wherein the amplitude of high frequency pulse pairs ranges from about 0.3 milliamperes to about 0.8 milliamperes.

27. The method of claim 19, wherein the amplitude of low frequency pulse pairs ranges from about 1 milliamperes to about 3 milliamperes.

28. The method of claim 27, wherein the amplitude of low frequency pulse pairs ranges from about 1.3 milliamperes to about 1.7 milliamperes.

29. The method of claim 19, wherein the high frequency pulses have pulse widths in a range of about 0.01 ms to about 0.5 ms.

30. The method of claim 19, wherein the high frequency pulses have pulse widths in a range of about 0.08 ms to about 0.12 ms.

31. The method of claim 19, wherein the low frequency pulses have pulse widths in a range of about 0.1 ms to about 1.0 ms.

32. A system for controlling a bladder or bowel, said system comprising:

an electrical pulse generator configured to produce alternate phase high frequency, low amplitude pulses and an alternate phase low frequency, high amplitude pulses to a sacral nerve;

at least one electrode that can be coupled to a nerve and transmit an electrical signal from said pulse generator to said nerve; and

a pressure sensitive switch on the electrical pulse generator.

33. The system of claim 32, wherein said electrode is coupled to the sacral nerve and in electrical communication with the electrical pulse generator.

34. The system of claim 32, wherein the system comprises two electrodes coupled to the electrical pulse generator with four wires.