Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation

• US 6,990,377 B2
• Filed: 04/26/2004
• Issued: 01/24/2006
• Est. Priority Date: 04/24/2003
• Status: Expired due to Fees

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Northstar Neuroscience, Inc.
• Inventors: Gliner, Bradford E., Sheffield, Warren D.
• Primary Examiner(s): Manuel, George
• Application Number:
  US10/832,477
• Publication Number:
  US 20050004624A1
• Time in Patent Office: 638 Days
• Field of Search: 607/46, 607/53, 607/54, 600/546, 600/558, 623/24
• US Class Current: 607/54
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke

Abstract

System and methods for effectuating and/or facilitating visual function in a patient. One embodiment of a system comprises a neural stimulation system and a visual training system. The neural stimulation system can include a pulse generator and a stimulus delivery device coupled to the pulse generator. The stimulus delivery device is configured to deliver a stimulus to the brain of the patient. The visual training system can include a computer and a display coupled to the computer. The computer has a computer operable medium containing instructions to provide a visual output to the patient via the display.

Claims

1. A system for effectuating and/or facilitating visual function in a patient, comprising:

a neural stimulation system including a pulse generator and a stimulus delivery device coupled to the pulse generator, the stimulus delivery device being configured to deliver a stimulus to the brain of the patient via a pathway that does not include the cornea; and

a visual training system including a computer and a display coupled to the computer, the computer having a computer operable medium containing instructions to provide a visual output to the patient via the display.

2. The system of claim 1 wherein the pulse generator is configured to be subcutaneously implanted into the patient, and wherein the pulse generator comprises an energy storage device and an electrically operable medium containing instructions to generate and deliver an electrical stimulus to the patient.

3. The system of claim 1 wherein the stimulus delivery device comprises a cortical electrode configured to be implanted in the patient at a location proximate to the cortex.

4. The system of claim 1 wherein:

the stimulus delivery device comprises a cortical electrode configured to be implanted in the patient at a location proximate to the cortex;

the pulse generator is configured to be implanted into the patient, the pulse generator having an energy storage device and an electrically operable medium containing instructions to generate an electrical pulse; and

wherein the system further comprises

a lead electrically coupled to the electrode and the pulse generator to deliver the electrical pulse to the electrode.

5. The system of claim 1 wherein the stimulus delivery device comprises a cortical electrode array including a dielectric carrier and a plurality of electrodes on the dielectric carrier.

6. The system of claim 1 wherein the stimulus delivery device comprises a cortical electrode array including a flexible carrier and a plurality of electrodes on the carrier.

7. The system of claim 1 wherein the stimulus device comprises a deep brain electrode and/or a nerve cuff electrode.

8. The system of claim 1 wherein the computer operable instructions generate a fixation image on the display.

9. The system of claim 1 wherein the computer operable instructions generate a series of images on the display.

10. A method for effectuating and/or facilitating visual function in a patient, comprising:

identifying a neural stimulation site corresponding to neural activity associated with the visual function, and at which neuroplasticity is occurring and/or may be expected to occur to carry out the visual function; and

applying neural stimulation to a population of neurons at the stimulation site via a pathway that does not include the cornea.

11. The method of claim 10 wherein:

applying the neural stimulation comprises implanting a cortical electrode in the patient proximate to the cortex and delivering an electrical stimulus directly to the cortex via the implanted electrode and wherein the method further comprises;

providing a visual input to the patient for visual training and/or tasking; and

monitoring a response in the patient.

12. The method of claim 10 wherein identifying a neural stimulation site comprises determining a location of a target population of neurons in the cortex where neuroplasticity is occurring and/or may be expected to occur to carry out the visual function.

13. The method of claim 10 wherein identifying a neural stimulation site comprises imaging neural activity using functional MRI while providing a visual input to the patient and determining a target population of neurons in the cortex associated with the visual function.

14. The method of claim 10 wherein identifying a neural stimulation site comprises selecting at least one of the occipital lobes of the cortex.

15. The method of claim 10 wherein applying stimulation comprises implanting a cortical electrode in the patient proximate to the dura of the cortex and delivering an electrical stimulus directly to the cortex via the implanted electrode.

16. The method of claim 10 wherein applying stimulation comprises delivering an electromagnetic stimulation transcutaneously through the cranium.

17. The method of claim 10, further comprising performing visual training while applying the neural stimulation.

18. The method of claim 17 wherein performing the visual training comprises instructing the patient to visually focus on a fixation object.

19. The method of claim 17 wherein performing the visual training comprises delivering optical stimulation to the patient'"'"'s eyes.

20. The method of claim 17 wherein performing the visual training comprises delivering optical stimulation to visual field zones corresponding to reduced, limited and/or residual visual function.

21. The method of claim 10 further comprising evaluating patient performance.

22. The method of claim 21 wherein evaluating patient performance comprises receiving feedback from the patient via a computer input device.

23. The method of claim 10 further comprising adjusting a stimulation parameter and reapplying the neural stimulation.

24. A method for effectuating and/or facilitating visual function in a patient, comprising:

implanting an electrode at an occipital lobe of the patient proximate to the dura of the cortex;

implanting a pulse generator in the patient and electrically coupling the pulse generator to the electrode; and

applying electrical pulses to the electrode.

25. The method of claim 24 wherein applying electrical pulses comprises generating a continuous pulse train of pulses.

26. The method of claim 24 further comprising performing visual training while applying the electrical pulses to the electrode.

27. The method of claim 26 wherein performing the visual training comprises instructing the patient to visually focus on a fixation object.

28. The method of claim 26 wherein performing the visual training comprises delivering optical stimulation to the eyes of the patient.

29. The method of claim 26 further comprising adjusting a stimulation parameter and reapplying different electrical pulses to the electrode.

30. A system for effectuating and/or facilitating visual function in a patient, comprising:

a neural stimulation system including a pulse generator and a stimulus delivery device coupled to the pulse generator, the stimulus delivery device being configured to deliver a stimulus to the brain of the patient, the stimulus delivery device comprising a cortical electrode configured to be implanted in the patient at a location proximate to the cortex; and

a visual training system including a computer and a display coupled to the computer, the computer having a computer operable medium containing instructions to provide a visual output to the patient via the display.

31. The system of claim 30 wherein the pulse generator is configured to be subcutaneously implanted into the patient, and wherein the pulse generator comprises an energy storage device and an electrically operable medium containing instructions to generate and deliver an electrical stimulus to the patient.

32. The system of claim 30 wherein:

the pulse generator is configured to be implanted into the patient, the pulse generator having an energy storage device and an electrically operable medium containing instructions to generate an electrical pulse; and

wherein the system further comprises

a lead electrically coupled to the electrode and the pulse generator to deliver the electrical pulse to the electrode.

33. The system of claim 30 wherein the stimulus delivery device comprises a cortical electrode array including a dielectric carrier and a plurality of electrodes on the dielectric carrier.

34. The system of claim 30 wherein the stimulus delivery device comprises a cortical electrode array including a flexible carrier and a plurality of electrodes on the carrier.

35. The system of claim 30 wherein the computer operable instructions generate a fixation image on the display.

36. The system of claim 30 wherein the computer operable instructions generate a series of images on the display.

37. A method for effectuating and/or facilitating visual function in a patient, comprising:

identifying a neural stimulation site corresponding to neural activity associated with the visual function, and at which neuroplasticity is occurring and/or may be expected to occur to carry out the visual function; and

applying neural stimulation to a population of neurons at the stimulation site by implanting a cortical electrode in the patient and delivering an electrical stimulus to the cortex via the implanted electrode.

38. The method of claim 37 wherein:

identifying a neural stimulation site comprises determining a location of a target population of neurons in the cortex where neuroplasticity is occurring and/or may be expected to occur to carry out the visual function;

applying the neural stimulation comprises implanting a cortical electrode in the patient proximate to the cortex and delivering an electrical stimulus directly to the cortex via the implanted electrode;

providing a visual input to the patient for visual training and/or tasking; and

monitoring a response in the patient.

39. The method of claim 37 wherein identifying a neural stimulation site comprises determining a location of a target population of neurons in the cortex where neuroplasticity is occurring and/or may be expected to occur to carry out the visual function.

40. The method of claim 37 wherein identifying a neural stimulation site comprises imaging neural activity using functional MRI while providing a visual input to the patient and determining a target population of neurons in the cortex associated with the visual function.

41. The method of claim 37 wherein identifying a neural stimulation site comprises selecting at least one of the occipital lobes of the cortex.

42. The method of claim 37, further comprising performing visual training while applying the neural stimulation.

43. The method of claim 42 wherein performing the visual training comprises instructing the patient to visually focus on a fixation object.

44. The method of claim 42 wherein performing the visual training comprises delivering optical stimulation to the patient'"'"'s eyes.

45. The method of claim 42 wherein performing the visual training comprises delivering optical stimulation to visual field zones corresponding to reduced, limited and/or residual visual function.

46. The method of claim 37 further comprising adjusting a stimulation parameter and reapplying the neural stimulation.