Diagnostic method and apparatus using light

• US 6,990,426 B2
• Filed: 03/14/2003
• Issued: 01/24/2006
• Est. Priority Date: 03/16/2002
• Status: Expired due to Term

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Kim, Hong-sig, Yoon, Gil-won, Park, Kun-kook, Kim, Su-jin, Lee, Jong-youn, Jeon, Kye-jin, Jwa, Hoon-jong
• Primary Examiner(s): Hoff, Marc S.
• Assistant Examiner(s): MILLER, CRAIG S
• Application Number:
  US10/387,552
• Publication Number:
  US 20030236647A1
• Time in Patent Office: 1,047 Days
• Field of Search: 702/21, 702/26, 702/139, 702189-195, 600476-484, 600500-508
• US Class Current: 702/139
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence

Abstract

A diagnosis method and apparatus for measuring blood hemoglobin concentration, oxygen saturation, pulse rate, respiration rate, or degree of aging of blood vessels using light includes an input/output unit for receiving a command for measurement from a user and for providing information on the result of a measurement to the user; a control unit for receiving the command for measurement from the input/output unit and for generating a control signal; a light generating unit for generating at least two light beams for measurement according to the control signal; a light receiving unit for receiving the light beams transmitted through an object that is subject to measurement and for converting the received light beams into electrical signals; and a data processing unit for processing the electrical signals received from the light receiving unit and for outputting information on the result of a predetermined measurement.

Claims

1. A diagnosis apparatus using light, comprising:

an input/output unit for receiving a command for measurement from a user and for providing information on the result of a measurement to the user;

a control unit for receiving the command for measurement from the input/output unit and for generating a control signal;

a light generating unit for generating at least two light beams, each light beam having an initial intensity, for measurement according to the control signal;

a light receiving unit for detecting the intensity of each of the at least two light beams after transmission through an object that is subject to measurement and for converting the received light beams into electrical signals; and

a data processing unit for processing the electrical signals received from the light receiving unit and for outputting information on the result of a predetermined measurement to the input/output unit, the data processing unit including a degree of aging of blood vessels calculation portion for receiving the electrical signals from the light receiving unit, for extracting a first pulse wave signal having a frequency corresponding to an average pulse rate per minute for humans from the received electrical signals, for differentiating the extracted first pulse wave signal into a second pulse wave signal to detect inflection points therein, for calculating a diagnostic index for the degree of aging of blood vessels using the values of the inflection points, and for calculating a degree of aging of blood vessels using the calculated diagnostic index, based on a correlation between the degrees of aging of blood vessels and diagnostic indices therefor.

2. The diagnosis apparatus as claimed in claim 1, wherein the light generating unit comprises:

a digital-to-analog converter for receiving the control signal from the control unit and for converting the received control signal into an analog signal;

a light emitting diode driver for driving a light emitting diode to generate the at least two light beams according to the analog signal; and

a light radiator for radiating the generated light beams onto the object.

3. The diagnosis apparatus as claimed in claim 1, wherein the light receiving unit comprises:

a photodetector for detecting the intensities of the at least two light beams after transmission through the object and for converting the detected light beam intensities into analog electrical signals;

a low-pass filter for filtering out a high frequency component of the analog electrical signals; and

an analog-to-digital converter for converting the analog electrical signals into digital electrical signals.

4. The diagnosis apparatus as claimed in claim 1, wherein the data processing unit comprises:

a data storage portion for storing measured results and for outputting to the input/output unit a calculated result according to a control signal of the control unit.

5. The diagnosis apparatus as claimed in claim 1, wherein the at least two light beams have different wavelengths.

6. The diagnosis apparatus as claimed in claim 1, wherein the at least two light beams are selected from a range of wavelengths in which the extinction coefficient for water is smaller than that of hemoglobin.

7. The diagnosis apparatus as claimed in claim 1, wherein each of the at least two light beams have a wavelength no longer than 1300 nm.

8. The diagnosis apparatus as claimed in claim 1, wherein the at least two light beams are isobestic.

9. The diagnosis apparatus as claimed in claim 1, wherein each of the at least two light beams has a wavelength selected from the group consisting of 422 nm, 453 nm, 499 nm, 529 nm, 546 nm, 569 nm, 584 nm, 805 nm, and 1300 nm.

10. The diagnosis apparatus as claimed in claim 1, wherein the data processing unit further comprises:

a ratio calculation portion for receiving the electrical signals from the light receiving unit and for calculating, for each wavelength of the at least two light beams, a ratio of the intensity of the light received by the light receiving unit with respect to the initial intensity of the light radiated from the light generating unit; and

a hemoglobin concentration and oxygen saturation calculation portion for calculating a hemoglobin concentration value using the ratio calculated by the ratio calculation portion based on a correlation between light intensity variations and hemoglobin concentrations and for calculating an oxygen saturation value using the calculated hemoglobin concentration value.

11. The diagnosis apparatus as claimed in claim 1, wherein the data processing unit further comprises:

a pulse rate calculation portion for receiving the electrical signals from the light receiving unit, for extracting a pulse wave signal having a frequency corresponding to an average pulse rate per minute for humans from the received electrical signals, and for calculating a pulse rate based on an average time interval between peaks detected from the extracted pulse wave signal.

12. The diagnosis apparatus as claimed in claim 1, wherein the data processing unit further comprises:

a respiration rate calculation portion for receiving the electrical signals from the light receiving unit, for extracting a respiration signal having a frequency corresponding to an average respiration rate per minute for humans from the received electrical signals, and for calculating a respiration rate based on an average time interval between peaks detected from the extracted respiration signal.

13. A diagnosis method using light, comprising:

(a) receiving a command for measurement from a user;

(b) generating a control signal according to the received command for measurement;

(c) generating at least two light beams, each light beam having an initial intensity, for measurement according to the control signal;

(d) radiating the at least two light beams onto an object that is subject to measurement, detecting the intensities of the at least two light beams after transmission through the object, and converting the detected intensities of the at least two light beams into electrical signals; and

(e) processing the electrical signals to obtain information on the result of a predetermined measurement, including

extracting a first pulse wave signal having a frequency corresponding to an average pulse rate per minute for humans from the electrical signals obtained in (d);

differentiating the extracted first pulse wave signal into a second pulse wave signal to detect inflection points therein;

calculating a diagnostic index for the degree of aging of blood vessels using the values of the inflection points; and

calculating a degree of aging of blood vessels using the calculated diagnostic index, based on a correlation between the degrees of aging of blood vessels and diagnostic indices therefor.

14. The diagnosis method as claimed in claim 13, wherein generating the at least two light beams comprises:

(c1) receiving the control signal and converting the received control signal into an analog signal;

(c2) generating the at least two light beams according to the analog signal; and

(c3) radiating the generated light beams onto the object.

15. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 14.

16. The diagnosis method as claimed in claim 13, wherein radiating the light beams onto an object comprises:

(d1) detecting the intensities of the at least two light beams after transmission through the object and converting the detected light beam intensities into analog electrical signals;

(d2) filtering out a high frequency component of the analog electrical signals; and

(d3) converting the analog electrical signals into digital electrical signals.

17. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 16.

18. The diagnosis method as claimed in claim 13, further comprising providing the result of the predetermined measurement to the user.

19. The diagnosis method as claimed in claim 18, wherein the user is remotely located from the object subject to measurement.

20. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 18.

21. The diagnosis method as claimed in claim 13, further comprising:

storing the information on the result of the predetermined measurement.

22. The diagnosis apparatus as claimed claim 13, wherein the at least two light beams have different wavelengths.

23. The diagnosis apparatus as claimed in claim 13, wherein the at least two light beams are selected from a range of wavelengths in which the extinction coefficient for water is smaller than that of hemoglobin.

24. The diagnosis apparatus as claimed in claim 13, wherein each of the at least two light beams have a wavelength no longer than 1300 nm.

25. The diagnosis apparatus as claimed in claim 13, wherein the at least two light beams are isobestic.

26. The diagnosis apparatus as claimed in claim 13, wherein each of the at least two light beams has a wavelength selected from the group consisting of 422 nm, 453 nm, 499 nm, 529 nm, 546 nm, 569 nm, 584 nm, 805 nm, and 1300 nm.

27. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 13.

28. The diagnosis method as claimed in claim 13, wherein processing the electrical signals further comprises:

calculating, for each wavelength of the at least two light beams, a ratio of the intensity of the light beam detected in (d) with respect to the initial intensity of the light generated in (c); and

calculating a hemoglobin concentration value using the ratio of the intensity of the light beam based on a correlation between light intensity variations and hemoglobin concentrations and calculating an oxygen saturation value using the calculated hemoglobin concentration value.

29. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 28.

30. The diagnosis method as claimed in claim 13, wherein processing the electrical signals further comprises:

extracting a pulse wave signal having a frequency corresponding to an average pulse rate per minute for humans from the electrical signals obtained in (d); and

calculating a pulse rate based on an average time interval between peaks detected from the extracted pulse wave signal.

31. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 30.

32. The diagnosis method as claimed in claim 13, wherein processing the electrical signals further comprises:

extracting a respiration signal having a frequency corresponding to an average respiration rate per minute for humans from the electrical signals obtained in (d); and

calculating a respiration rate based on an average time interval between peaks detected from the extracted respiration signal.

33. A computer readable medium having embodied thereon a computer program for the diagnosis method according to claim 32.