Hollow fiber contactor systems for removal of lipids from fluids

• US 6,991,727 B2
• Filed: 02/16/2005
• Issued: 01/31/2006
• Est. Priority Date: 06/25/2001
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Lipid Sciences, Inc.
• Inventors: Malhotra, Ripudaman, Low, Thomas P., Hegwer, Eric, Garcia, Pablo E., Bomberger, David C.
• Primary Examiner(s): Walker, W. L.
• Assistant Examiner(s): Menon, Krishnan S
• Application Number:
  US11/059,064
• Publication Number:
  US 20050133450A1
• Time in Patent Office: 349 Days
• Field of Search: 210/252, 210/253, 210/255, 210/257.2, 210/263, 210/321.79, 210/321.8, 210/645, 210/649, 210/660, 210804-807, 604/5.03
• US Class Current: 210/321.78
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3468 using treated filtrate as substitution fluid
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3482 by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 2202/0456 Lipoprotein
• CPC Class Codes: A61M 2202/08 Lipoids
• CPC Class Codes: A61M 2202/203 Bacteria
• CPC Class Codes: A61M 2202/206 Viruses
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: B01D 11/043 with stationary contacting elements, sieve plates or loose contacting elements
• CPC Class Codes: B01D 11/0492 Applications, solvents used
• CPC Class Codes: B01D 2313/50 Specific extra tanks
• CPC Class Codes: B01D 61/246 : Membrane extraction
• CPC Class Codes: B01D 61/362 : Pervaporation
• CPC Class Codes: B01D 63/02 : Hollow fibre modules
• CPC Class Codes: B01D 63/046 : in separate housings

Abstract

This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

Claims

1. A system for removing at least one lipid from a fluid containing lipids or lipid-containing organisms, comprising:

an initial phase subsystem comprising;

a fluid source containing the fluid and coupled to a first device that combines the fluid with a first extraction solvent;

a first extraction solvent source containing the first extraction solvent and coupled to the first device; and

the first device comprising at least one hollow fiber contactor, wherein the first device receives and mixes the fluid from the fluid source and the first extraction solvent from the first extraction solvent source, forming a first mixture and dissolving at least a portion of the lipids;

an intermediate phase subsystem comprising;

a second extraction solvent source containing a second extraction solvent and coupled to a second device that combines the first mixture with the second extraction solvent;

the second device comprising at least one hollow fiber contactor and coupled to the first device, wherein the second device receives and mixes the first mixture from the first device and the second extraction solvent from the second extraction solvent source, forming a second mixture and dissolving additional lipids and at least a portion of the first extraction solvent;

a final phase subsystem comprising;

a third device comprising at least one hollow fiber contactor and coupled to the second device, wherein the third device receives the second mixture and contacts the second mixture with a gas or mineral oil, removing at least a portion of any remaining solvents from the second mixture.

2. The system of claim 1, further comprising an extraction solvent waste receptacle coupled to the first, second, and third devices.

3. The system of claim 1, wherein the initial phase subsystem further comprises a saline source coupled to the first device.

4. The system of claim 3, wherein the initial phase subsystem further comprises:

a first pump disposed between the fluid source and the first device that transfers the fluid to the first device;

a second pump disposed between the first extraction solvent source and the first device that transfers the first extraction solvent to the first device; and

a third pump disposed between the saline source and the first device that transfers saline to the first device.

5. The system of claim 4, wherein the intermediate phase subsystem further comprises a fourth pump disposed between the second extraction solvent source and the second device that transfers the second extraction solvent to the second device.

6. The system of claim 1, wherein the final phase subsystem further comprises a sensor that detects levels of the first extraction solvent, the second extraction solvent, or both, the sensor coupled to a conduit disposed adjacent an exit opening of the third device.

7. The system of claim 1, wherein the final phase subsystem further comprises:

a pervaporation buffer source coupled to a conduit that connects the second device to the third device, the pervaporation buffer source including a sensor that detects levels of the first extraction solvent, the second extraction solvent, or both within the second mixture.

8. The system of claim 1, wherein the final phase subsystem further comprises a gas filtering loop that removes the first extraction solvent and the second extraction solvent from the gas.

9. The system of claim 8, wherein the gas filtering loop further comprises:

a carbon bed coupled to the third device such that the carbon bed receives gas having first and second extraction solvents;

two filters and two pressure regulators disposed downstream of the carbon bed; and

a pump that circulates gas through the gas filtering loop and the third device.

10. The system of claim 1, wherein the final phase subsystem is a recirculating system that recirculates the second mixture through the third device until solvent levels are below a predetermined threshold.

11. The system of claim 10, wherein the final phase subsystem further comprises a recirculating vessel with at least two input ports and an output port, wherein an output port of the third device is coupled to a first input port of the recirculating vessel, an output port of the second device is coupled to a second input port of the recirculating vessel, and the output port of the recirculating vessel is coupled to an input port of the third device.

12. The system of claim 11, wherein the final phase subsystem further comprises a gas filtering loop that removes the first extraction solvent and the second extraction solvent from the gas.

13. The system of claim 12, wherein the final phase subsystem further comprises a sensor that detects levels of the first extraction solvent, the second extraction solvent, or both, the sensor coupled to a conduit disposed adjacent the outlet port of the recirculating vessel.

14. The system of claim 13, wherein the final phase subsystem further comprises at least one valve that directs the second mixture from the conduit adjacent the outlet port of the recirculating vessel (i) to an output buffer when solvent levels are below the predetermined threshold or (ii) to the third device when solvent levels are above the predetermined threshold.