Apparatus and methods for infrared calorimetric measurements
First Claim
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1. A plate for holding a plurality of samples, comprising:
- a frame;
a plurality of sample wells disposed in the frame for holding a corresponding plurality of samples; and
a thermal isolation structure associated with the frame and disposed between the sample wells to reduce thermal transfer between adjacent sample wells, where the thermal isolation structure comprises a thermal barrier disposed between adjacent sample wells to reduce thermal transfer between the adjacent sample wells, the thermal barrier including an infrared-reflective material that reflects at least about half of the thermal infrared radiation incident on the barrier.
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Abstract
Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.
238 Citations
58 Claims
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1. A plate for holding a plurality of samples, comprising:
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a frame; a plurality of sample wells disposed in the frame for holding a corresponding plurality of samples; and a thermal isolation structure associated with the frame and disposed between the sample wells to reduce thermal transfer between adjacent sample wells, where the thermal isolation structure comprises a thermal barrier disposed between adjacent sample wells to reduce thermal transfer between the adjacent sample wells, the thermal barrier including an infrared-reflective material that reflects at least about half of the thermal infrared radiation incident on the barrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A plate for holding a plurality of samples, comprising:
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a frame; a plurality of sample wells disposed in the frame for holding a corresponding plurality of samples; a thermal isolation structure associated with the frame and disposed between the sample wells to reduce thermal transfer between adjacent sample wells; and a plurality of trapped volumes corresponding to each sample well, the trapped volumes further reducing thermal transfer to and from samples in the sample wells, where the trapped volumes are formed between an outer surface of the sample wells and an inner surface of the corresponding isolation wells, and where at least a portion of the trapped volumes are lined by an infrared-reflective material. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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55. A plate device for holding a plurality of samples, comprising:
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an insert member defining an array of sample wells, each sample well having a central axis; and a support member having a thermal isolation framework in a configuration corresponding to the array of sample wells, where when the insert member engages the support member each sample well is thermally isolated from adjacent sample wells without obstructing the transmission of thermal infrared radiation along the central axis of the sample well, and where the thermal isolation framework comprises a thermal barrier disposed between adjacent sample wells to reduce thermal transfer between the adjacent sample wells, the thermal barrier including an infrared-reflective material that reflects at least about half of the thermal infrared radiation incident on the barrier. - View Dependent Claims (56, 57, 58)
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Specification