Polymeric coatings containing a pH buffer agent
First Claim
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1. A kit for preparing a solution for coating a medical device, the kit comprising a pH buffer agent, a cross-linkable polymer, and a cross-linking compound for cross-linking the polymer, wherein the pH buffer agent, the cross-linkable polymer, and the cross-linking compound are three components of the coating solution, the pH buffer agent minimizes pH changes on the surface of the medical device;
- the pH buffer agent including inorganic salts, the cross-linkable polymer being polyurethane having carboxylate groups, and the cross-linking compound being an aziridine, carbodiimide, or epoxy silane.
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Abstract
A device containing a support member, a cross-linked polymer, and a pH buffer agent. A surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded.
32 Citations
5 Claims
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1. A kit for preparing a solution for coating a medical device, the kit comprising a pH buffer agent, a cross-linkable polymer, and a cross-linking compound for cross-linking the polymer, wherein the pH buffer agent, the cross-linkable polymer, and the cross-linking compound are three components of the coating solution, the pH buffer agent minimizes pH changes on the surface of the medical device;
- the pH buffer agent including inorganic salts, the cross-linkable polymer being polyurethane having carboxylate groups, and the cross-linking compound being an aziridine, carbodiimide, or epoxy silane.
- View Dependent Claims (2, 3)
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4. A medical device comprising a support member, a cross-linked polymer, and a pH buffer agent, wherein a surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded, and the pH buffer agent minimizes pH changes on the surface of the support member;
- the pH buffer agent including potassium phosphate monobasic and sodium phosphate dibasic so as the maintain pH 6-6.8, and the cross-linked polymer being water-based, hydrophobic polyurethane.
- View Dependent Claims (5)
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Current AssigneeAST Products Incorporated
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Original AssigneeAST Products Incorporated
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InventorsSheu, Min-Shyan, Lin, Tung-Liang, Loh, Ih-Huong
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Primary Examiner(s)Wu, David W.
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Assistant Examiner(s)Lee, Rip A.
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Application NumberUS10/303,226Publication NumberTime in Patent Office1,163 DaysField of Search524/590, 524/417, 524/438, 524/589, 604/21, 604/264, 424/423US Class Current524/414CPC Class CodesA61L 27/34 Macromolecular materialsA61L 27/54 Biologically active materia...A61L 31/10 Macromolecular materialsA61L 31/16 Biologically active materia...C08K 3/32 Phosphorus-containing compo...
