Crystallization of amino acids using ultrasonic agitation
First Claim
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1. A process of crystallizing L-thyroxine comprising subjecting a solution of L-thyroxine or a salt thereof to ultrasonic agitation at a temperature and for a period of time sufficient to produce a crystalline form of said L-thyroxine.
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Abstract
A method for reducing the particle size of amino acid crystals using ultrasound is discussed.
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33 Claims
- 1. A process of crystallizing L-thyroxine comprising subjecting a solution of L-thyroxine or a salt thereof to ultrasonic agitation at a temperature and for a period of time sufficient to produce a crystalline form of said L-thyroxine.
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32. A process for crystallizing sodium L-thyroxine, comprising subjecting an aqueous solution of sodium L-thyroxine to ultrasonic agitation while the solution is cooled to a temperature and for a period of time sufficient to produce a crystalline form of the sodium L-thyroxine having a particle size less than about 18 microns.
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