Linking neurophysiological and neuropsychological measures for cognitive function assessment in a patient

• US 6,993,381 B2
• Filed: 10/23/2003
• Issued: 01/31/2006
• Est. Priority Date: 10/25/2002
• Status: Active Grant

• Current Assignee: John F. Connolly, Ryan Cn D'Arcy, Yannick Marchand
• Original Assignee: John F. Connolly, Ryan Cn D'Arcy, Yannick Marchand
• Inventors: Marchand, Yannick, D'Arcy, Ryan C. N., Connolly, John F.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/690,845
• Publication Number:
  US 20040138582A1
• Time in Patent Office: 831 Days
• Field of Search: 600544-545
• US Class Current: 600/544
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence

Abstract

A method for cognitive function assessment in a patient uses the ERP waveform features and parameters that maximize the correlation between the ERP components and behavioral performance on a neuropsychological test of language comprehension (PPVT-R). The method provides an electrophysiological diagnostic technique that can be used in the assessment of aphasic patients. ERPs are recorded during a computerized version of the Peabody Picture Vocabulary Test-Revised (PPVT-R, Form M). In the computerized version, a picture is presented followed by a congruent or incongruent spoken word. A derived measure is calculated from the ERP differentiation between congruent and incongruent words. The N400 is the primary component elicited to incongruent spoken words.

Claims

1. A method for cognitive function assessment in a patient comprising:

adapting a standardized psychometric test to a computer format to produce a computerized standardized psychometric neuropsychological test for presentation of stimuli to the patient;

simultaneously presenting the test to the patient and recording the patient'"'"'s event-related potential (ERP) obtained from an EEG (electroencephalogram) to generate ERP data;

applying algorithms that relate the ERP data to behavioral data through a regression line in an interpretable manner within the context of standardized psychometric tests;

using this regression line to interpret the ERP data within the context of standardized psychometric tests even in the absence of behavior/performance measures;

and making prognosis of the patient using the ERP data;

wherein the steps of the method are conducted in such a manner as to permit the evaluation of a patient'"'"'s state of mental functioning using the ERP data even if the patient is unable to verbally or behaviorally perform the test in a typical fashion.

2. A method for cognitive function assessment in a patient comprising:

adapting a neuropsychological test to a computer format to produce a computerized standardized psychometric neuropsychological test for presentation of stimuli to the patient;

simultaneously presenting the test to the patient and recording the patient'"'"'s electroencephalographic (EEG) signals to effect recording of late-occurring “

cognitive”

event-related potentials (ERP) from a number of locations on the patient'"'"'s head to provide ERP data;

applying a series of analysis algorithms that relate the ERP data to obtained behavioral data in an interpretable manner;

applying a series of analysis algorithms that permit interpretation of the ERP data within the context of the test'"'"'s framework even in the absence of behavioral data;

and making a prognosis of patient outcome using the ERP data obtained using the test;

wherein the steps of the method are conducted in such a manner as to permit the evaluation of a patient'"'"'s state of mental functioning using the ERP data even if the patient is unable to verbally or behaviorally perform the test in a typical fashion.

3. The method according to claim 2 including using the steps of the method to evaluate patient progress through medical treatment using the ERP data obtained using the test.

4. The method according to claim 2 wherein the analysis algorithms use the Pearson correlation coefficient to evaluate the strength of an association between the ERP data and the obtained behavioral data.

5. The method according to claim 2 wherein the analysis algorithms use waveform features and parameters that maximize the correlation between the ERP data and test scores of the test.

6. The method according to claim 2 wherein the test applied assesses the function of semantic comprehension ability and wherein the analysis algorithms use the N400 component of the ERP data.

7. The method according to claim 2 wherein the test applied assesses the function of memory ability and wherein the analysis algorithms use the P300 and the LPC (late positive component) of the ERP data.

8. The method according to claim 2 wherein the analysis algorithms use a discrimination which is formally expressed using serial t-scores that provide a statistical method of comparing two waveforms on a point-by-points basis to establish where they differed in time.

9. The method according to claim 8 wherein the analysis algorithms used act to calculate the variance for each point in the waveform necessary to achieve the t-scores using homologous points in each of the trials that went into making up the two waveforms, wherein one waveform is congruent and the other is incongruent.

10. The method according to claim 8 wherein a succession of sums of t-scores is obtained for each of three levels of difficulty of the test across three electrode sites, the three sites being Fz, Cz and Pz.

11. The method according to claim 10 wherein the sums are calculated in a temporal interval that is both centered to the peak latency and increased in a step-wise fashion by 40 milliseconds, that is semi-intervals of 20 ms on each side of the peak.

12. The method according to claim 8 wherein the analysis algorithms obtain one baseline case that is composed of a single t-score at the peak and ten different sums of t-scores obtained from ten different semi-intervals varying by 20 ms from 20 ms to 200 ms.

13. The method according to claim 2 wherein the test comprises the first level of a computerized Peabody Picture Vocabulary Test PPVT in conjunction with a centro-parietal montage (Cz and Pz).

14. The method according to claim 2 wherein, if a linear relationship links certain elements of the ERP data to Peabody Picture Vocabulary Test-Revised PPVT-R scores, then the correlation coefficients that numerically express this relationship are used to elucidate which waveform features are critical.

15. The method according to claim 5 wherein the analysis algorithms are used to obtain the waveform features and strategies that provide the highest Pearson correlation between the ERP data and neuropsychological performance.

16. The method according to claim 8 wherein the analysis algorithms are used to obtain the sum of the t-scores between two compared waveforms for the patient at each or among any combination of electrodes for a temporal interval that is the sum that is correlated with the behavioral performance of the patient.

17. The method according to claim 8 wherein the analysis algorithms are used to take the highest sum of t-scores between two compared waveforms for the patient among any combination of electrodes for a temporal interval that is the highest value that is correlated with the behavioral performance of the patient.

18. The method according to claim 17 wherein the analysis algorithms are used to obtain the temporal interval and the combination of electrodes which produce the highest Pearson correlation between the ERP data and neuropsychological performance.

19. The method according to claim 18 wherein the equation for the linear regression is based on the highest Pearson correlation to predict behavioral performance using only ERP data measures which are comprised of features and strategies.

20. A method for cognitive function assessment in a patient comprising:

adapting a neuropsychological test to a computer format to produce a computerized standardized psychometric neuropsychological test for presentation of stimuli to the patient;

wherein the patient is unable to verbally or behaviorally perform the test in a typical fashion;

simultaneously presenting the test to the patient and recording the patient'"'"'s electroencephalographic (EEG) signals to effect recording of late-occurring “

cognitive”

event-related potentials (ERP) from a number of locations on the patient'"'"'s head to provide ERP data even in the absence of behavioral data from the test on the patient;

applying a series of analysis algorithms that relate the ERP data obtained in the test to obtained behavioral data in an interpretable manner;

applying a series of analysis algorithms that permit interpretation of the ERP data within the context of the test'"'"'s framework;

and making a prognosis of patient outcome using the ERP data obtained using the test.