Systems for applying cross-linked mechanical barriers
First Claim
1. A system for applying a biocompatible, non-liquid barrier matrix to seal a vascular puncture site comprisinga catheter device defining a catheter tube movable into association with the vascular puncture site, the catheter tube including a distal end with an outlet, the catheter device including a positioner comprising an expandable structure on the distal end of the catheter tube to locate the outlet with respect to the vascular puncture sitea first dispenser containing a protein component,a second dispenser containing a polymer component comprising poly(ethylene) glycol (PEG) with a functionality of at least three, andan introducer attachable in communication with the catheter tube and including a holder to mutually support the first and second dispensers while conveying the protein and polymer components from the dispensers into the catheter tube for mixing as a result of flow through the catheter tube toward the outlet, wherein, upon mixing, the protein and polymer components chemically cross-link to form the non-liquid harder matrix at the vascular puncture site without the use of a photo initiator and ultraviolet light.
2 Assignments
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Accused Products
Abstract
A delivery device applies a biocompatible and biodegradable barrier material to a tissue region, e.g., to seal a vascular puncture site. The material comprises two liquid components, which are pre-packaged in individual dispensers. Upon mixing, the liquid components cross-link to create a barrier matrix. A holder attaches to the delivery device. The holder mutually supports the first and second dispensers while the protein solution and polymer solution are conveyed from the dispensers into a fluid delivery channel. The protein and polymer solutions mix as a result of flow through the channel.
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Citations
13 Claims
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1. A system for applying a biocompatible, non-liquid barrier matrix to seal a vascular puncture site comprising
a catheter device defining a catheter tube movable into association with the vascular puncture site, the catheter tube including a distal end with an outlet, the catheter device including a positioner comprising an expandable structure on the distal end of the catheter tube to locate the outlet with respect to the vascular puncture site a first dispenser containing a protein component, a second dispenser containing a polymer component comprising poly(ethylene) glycol (PEG) with a functionality of at least three, and an introducer attachable in communication with the catheter tube and including a holder to mutually support the first and second dispensers while conveying the protein and polymer components from the dispensers into the catheter tube for mixing as a result of flow through the catheter tube toward the outlet, wherein, upon mixing, the protein and polymer components chemically cross-link to form the non-liquid harder matrix at the vascular puncture site without the use of a photo initiator and ultraviolet light.
Specification