Medical device made from self-stiffening composite

• US 6,994,723 B1
• Filed: 05/21/2003
• Issued: 02/07/2006
• Est. Priority Date: 05/21/2003
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: McMahon, James C.
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Phan, Hieu
• Application Number:
  US10/442,796
• Time in Patent Office: 993 Days
• Field of Search: 623 139- 148
• US Class Current: 623/1.49
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2230/0054 V-shaped

Abstract

Medical devices are made from a self-stiffening composite including a base material, a polymerizer and a corresponding activator for the polymerizer. The medical devices have an initial configuration in which the polymerizer and activator are separated from each other and an activated configuration in which the polymerizer and activator are brought into contact with each other. Polymerization is triggered when the polymerizer and activator are contacted together, forming a polymer that stiffens the medical device. The medical device may thus be flexible in the initial configuration so it can be easily advanced through tortuous passageways during delivery to a body lumen and further have sufficient radial strength in the activated configuration to hold open the body lumen after implantation.

Claims

1. An expandable medical device having a delivery configuration and an expanded configuration, comprising:

a tubular body formed from the base material;

a polymerizer; and

a corresponding activator for the polymerizer, wherein the polymerizer and activator are dispersed in the base material, and wherein the medical device has an initial delivery configuration in which the polymerizer and activator are separated from each other and an expanded configuration in which the polymerizer and activator are brought into contact with each other.

2. The medical device of claim 1, wherein the polymerizer is contained within microspheres when the medical device is in the initial configuration.

3. The medical device of claim 2, wherein the medical device is configured to rupture the microspheres so as to release the polymerizer when the medical device is deployed in the activated configuration.

4. The medical device of claim 1, wherein the base material is a polymer.

5. The medical device of claim 1, wherein the polymerizer includes a monomer selected from the group consisting of cyclic olefins, lactones, lactams, acrylates, acrylic acids, alkyl acrylates, alkyl acrylic acids, styrenes, isoprene and butadiene.

6. The medical device of claim 5, wherein the corresponding activator for the polymerizer is selected from the group consisting of ROMP catalysts and cyclic ester polymerization catalysts.

7. The medical device of claim 1, wherein the base material embodies shape memory characteristics.

8. The medical device of claim 1, wherein the medical device is implantable in a human body.

9. The medical device of claim 8, wherein the implantable medical device is configured as a stent.

10. The medical device of claim 8, wherein the implantable medical device is configured as a vascular graft.

11. An expandable implantable intraluminal device, comprising:

a tubular body formed of a base material, a polymerizer contained within microspheres and a corresponding activator for the polymerizer, wherein the microspheres and activator are dispersed in the base material, the tubular body having a first delivery diameter in which the polymerizer and activator are separated from each other and a second expanded diameter in which the polymerizer and activator are brought into contact with each other.

12. The implantable intraluminal device of claim 11, wherein the tubular body is configured to rupture the microspheres so as to release the polymerizer when the implantable intraluminal device is deployed in the second expanded diameter.

13. A method for manufacturing an expandable medical device, comprising:

providing a tubular body formed from the base material;

dispersing a polymerizer and a corresponding activator for the polymerizer into the base material without contacting the polymerizer and the activator so as to form a mixture; and

forming an expandable medical device from the mixture wherein expansion causes said polymerizer and activator to contact one another.

14. The method of claim 13, further comprising incorporating the polymerizer into microspheres prior to dispersing the polymerizer into the base material.

15. The method of claim 13, wherein forming the medical device includes injection molding the mixture to form a tubular body.

16. The method of claim 15, wherein forming the medical device includes configuring an implantable device suitable for use in a human body.

17. The method of claim 16, wherein configuring the implantable device includes configuring a stent.

18. The method of claim 16, wherein configuring the implantable medical device includes configuring a vascular graft.

19. A method for manufacturing a medical device, comprising:

providing a tubular body formed from the base material;

forming a tubular body from the base material; and

dispersing a polymerizer and a corresponding activator for the polymerizer into the base material of the tubular body without contacting the polymerizer and the activator.

20. The method of claim 19, wherein dispersing the polymerizer and the activator into the base material of the tubular body includes immersing the tubular body in a mixture containing the polymerizer and the activator.

21. The method of claim 19, further comprising incorporating the polymerizer into microspheres prior to dispersing the polymerizer into the base material of the tubular body.

22. The method of claim 19, wherein forming the tubular body includes configuring a stent.

23. The method of claim 19, wherein forming the tubular body includes configuring a vascular graft.

24. A method of delivering an implantable intraluminal device to a desired location within a patient'"'"'s vasculature, the method comprising:

providing a delivery catheter having a distal end portion, a balloon formed on the distal end portion of the catheter, and an implantable intraluminal device disposed on the balloon and configured from a base material, a polymerizer, and a corresponding activator for the polymerizer, wherein the polymerizer and activator are dispersed in the base material;

advancing the distal end portion of the catheter, the balloon and the implantable intraluminal device though the vasculature to a desired location;

inflating the balloon so as to expand the implantable intraluminal device at the desired location and to contact the polymerizer with the activator;

deflating the balloon; and

withdrawing the catheter and the balloon from the vasculature.

25. The method of claim 24, wherein inflating the balloon so as to contact the polymerizer with the activator triggers polymerization of the polymerizer.

26. The method of claim 25, wherein deflating the balloon is performed after polymerization of the polymerizer is completed.