Delivery of stimulants through an inhalation route
First Claim
1. A condensation aerosol for delivery of a drug selected from the group consisting of ephedrine and fenfluramine wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patient through an inhalation route. The method comprises: a) heating a thin coating of a stimulant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% stimulant degradation products. In a kit aspect of the present invention, a kit for delivering a stimulant through an inhalation route is provided which comprises: a) a thin coating of a stimulant drug and b) a device for dispensing said thin coating a stimulant as a condensation aerosol.
251 Citations
26 Claims
- 1. A condensation aerosol for delivery of a drug selected from the group consisting of ephedrine and fenfluramine wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
-
4. A method of producing a drug selected from the group consisting of ephedrine and fenfluramine in an aerosol form comprising:
-
a. heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (5, 6, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A condensation aerosol for delivery of ephedrine, wherein the condensation aerosol is formed by heating a thin layer containing ephedrine, on a solid support, to produce a vapor of ephedrine, and condensing the vapor to form a condensation aerosol characterized by less than 5% ephedrine degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
24. A condensation aerosol for delivery of fenfluramine, wherein the condensation aerosol is formed by heating a thin layer containing fenfluramine, on a solid support, to produce a vapor of fenfluramine, and condensing the vapor to form a condensation aerosol characterized by less than 5% fenfluramine degradation products by weight, and an MMAD of 0.2 to 3 microns.
-
25. A method of producing ephedrine in an aerosol form comprising:
-
a. heating a thin layer containing ephedrine, on a solid support, to produce a vapor of ephedrine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% ephedrine degradation products by weight, and an MMAD of 0.2 to 3 microns.
-
-
26. A method of producing fenfluramine in an aerosol form comprising:
-
a. heating a thin layer containing fenfluramine, on a solid support, to produce a vapor of fenfluramine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% fenfluramine degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
Specification