Biocompatible carrier containing L-arginine
First Claim
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1. A composition for inhibiting the narrowing of a blood vessel, comprising an oligomer of L-arginine, L-arginine, an L-arginine analog, or an L-arginine analog oligomer linked through a labile bond to a polymeric matrix, wherein the composition is used for coating an implantation device to inhibit the narrowing of the blood vessel.
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Abstract
L-arginine conjugated to a polymeric matrix is disclosed. The matrix can be used as, for example, a coating for an implantable medical device such as a stent.
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33 Claims
- 1. A composition for inhibiting the narrowing of a blood vessel, comprising an oligomer of L-arginine, L-arginine, an L-arginine analog, or an L-arginine analog oligomer linked through a labile bond to a polymeric matrix, wherein the composition is used for coating an implantation device to inhibit the narrowing of the blood vessel.
- 10. A coating for a prosthetic device comprising a composition, the composition comprising an oligomer of L-arginine, L-arginine, an L-arginine analog, or an L-arginine analog oligomer linked through a labile bond to a polymeric matrix.
- 14. A method of coating a prosthesis comprising coating the prosthesis with a composition comprising an oligomer of L-arginine, L-arginine, L-arginine analog, or L-arginine analog oligomer linked through a labile bond to a polymeric matrix.
- 18. A stent coated with a coating comprising a composition for inhibiting the narrowing of a blood vessel, the composition comprising an oligomer of L-arginine, L-arginine, an L-arginine analog, or an L-arginine analog oligomer bonded linked through a labile bond to a polymeric matrix.
Specification