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Macromolecular arrays on polymeric brushes and methods for preparing the same

  • US 6,994,964 B1
  • Filed: 08/31/2000
  • Issued: 02/07/2006
  • Est. Priority Date: 09/01/1999
  • Status: Expired due to Term
First Claim
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1. A method of preparing a polymeric brush substrate having a plurality of polynucleotides thereon for use in a polynucleotide array, the method comprising:

  • (a) providing a substrate to which one or more free radical initiators are covalently attached, wherein each free radical initiator has a radical generation site distal to the substrate;

    (b) contacting the covalently attached substrate with monomers under conditions that promote free radical polymerization from the radical generation sites of the initiators to form a polymeric brush; and

    (c) covalently attaching a plurality of polynucleotides to a plurality of reactive groups on the polymeric brush.

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