Waveform interpreter for respiratory analysis

• US 6,997,880 B2
• Filed: 02/28/2002
• Issued: 02/14/2006
• Est. Priority Date: 06/08/1999
• Status: Expired due to Term

• Current Assignee: Oridion Medical 1987 Limited (Medtronic Plc)
• Original Assignee: Oridion Medical 1987 Limited (Medtronic Plc)
• Inventors: Carlebach, Ephraim, Krauss, Baruch Shlomo
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): Mallari, Patricia C.
• Application Number:
  US10/085,888
• Publication Number:
  US 20020082511A1
• Time in Patent Office: 1,447 Days
• Field of Search: 600300-301, 600529-543, 600309-313, 600322-327, 600/364, 73/233
• US Class Current: 600/529
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production

Abstract

A capnograph which performs an analysis of the breath waveforms measured by the carbon dioxide sensor, interprets the results of this analysis, and outputs to the operator diagnostic information about the respiratory status of the patient, or about the adequacy of the breathing support provided to the patient. The instrument compares a number of parameters characteristic of the waveforms of the patient'"'"'s breath with an internal library of the values of those parameters expected from normal waveforms stored in its memory. These parameters may either relate to specific features of the waveform in the time domain, or may characterize spectral components of the waveform in the frequency domain. The capnographic waveform analysis may be combined with further non-invasive measurements in order to provide an indication of the deviation of the value of EtCO₂ from PaCO₂.

Claims

1. Apparatus for computerized breath analysis comprising:

a breath receiver adapted to be placed in fluid communication with a subject;

a breath analyzer coupled to said breath receiver which analyzes at least one breath of the subject, wherein said apparatus provides an indication of the discrepancy between the end tidal carbon dioxide partial pressure in breath of the subject and the arterial carbon dioxide partial pressure of the subject; and

a corrector unit connected to said breath analyzer and operative to provide an indication of the arterial carbon dioxide partial pressure of the subject based on said discrepancy.

2. Apparatus for computerized breath analysis according to claim 1 and wherein said breath analyzer comprises a carbon dioxide analyzer and an oxygen analyzer.

3. Apparatus for computerized breath analysis according to claim 2 said apparatus also comprising a computational unit, and wherein:

said oxygen analyzer provides values of the partial pressures of inspired and expired oxygen in said at least one breath of the subject; and

said computational unit utilizes the difference between said values to provide said indication of the discrepancy between said end tidal carbon dioxide partial pressure in breath of the subject and said arterial carbon dioxide partial pressure of the subject.

4. Apparatus for computerized breath analysis according to claim 3 and wherein said discrepancy is utilized to provide an indication of the arterial carbon dioxide partial pressure of the subject.

5. Apparatus for computerized breath analysis according to claim 4 and also comprising a respiration diagnosis generator providing an indication of the respiratory status of the subject based on said indication of the arterial carbon dioxide partial pressure of the subject.

6. Apparatus for computerized breath analysis according to claim 4 and wherein said breath analyzer performs analysis of at least one breath waveform.

7. Apparatus for computerized breath analysis according to claim 1 and also comprising a respiration diagnosis generator providing an indication of the respiratory status of the subject based on said indication of said discrepancy between said end tidal carbon dioxide partial pressure in breath of the subject and said arterial carbon dioxide partial pressure of the subject.

8. Apparatus for computerized breath analysis according to claim 1 and wherein said breath analyzer performs analysis of at least one breath waveform.

9. Apparatus for computerized breath analysis according to claim 1 and also comprising a pulmonary volume meter, and wherein respiratory volume measured by said meter is utilized to provide said indication of the discrepancy between the end tidal carbon dioxide partial pressure in breath of the subject and the arterial carbon dioxide partial pressure of the subject.

10. Apparatus for computerized breath analysis according to claim 1 and also comprising a pulmonary volume meter, said pulmonary volume meter providing flow rate information, and wherein said flow rate information is utilized to provide said indication of the discrepancy between the end tidal carbon dioxide partial pressure in breath of the subject and the arterial carbon dioxide partial pressure of the subject.

11. Apparatus for computerized breath analysis according to claim 1 and also comprising a pulmonary volume meter, and wherein respiratory volume measured by said meter is utilized to provide said indication of the arterial carbon dioxide partial pressure of the subject.

12. Apparatus for computerized breath analysis according to claim 1 and also comprising a pulmonary volume meter, said pulmonary volume meter providing flow rate information, and wherein said flow rate information is utilized to provide said indication of the arterial carbon dioxide partial pressure of the subject.

13. Apparatus for computerized breath analysis according to claim 1 and also comprising at least one input receiving at least one non-respiratory measurement made on the subject, and wherein said at least one non-respiratory measurement made on the subject is utilized to provide said indication of the discrepancy between the end tidal carbon dioxide partial pressure in breath of the subject and the arterial carbon dioxide partial pressure of the subject.

14. Apparatus for computerized breath analysis according to claim 13 and wherein said at least one non-respiratory measurement made on the subject provides information about the condition of the blood circulation such that said information is used to correlate transfer of arterial carbon dioxide from the blood to the exhaled breath of the subject.

15. Apparatus for computerized breath analysis according to claim 13 and wherein said at least one non-respiratory measurement made on the subject provides information about the content of the blood such that said information is used to correlate transfer of arterial carbon dioxide from the blood to the exhaled breath of the subject.

16. Apparatus for computerized breath analysis according to claim 13 and wherein said at least one non-respiratory measurement made on the subject comprises at least one of:

an ECG measurement;

a pulse rate measurement;

a pulse oximetric measurement of arterial oxygen saturation level;

a cardiac output measurement; and

a body temperature measurement.

17. Apparatus for computerized breath analysis according to claim 1 and also comprising at least one input receiving at least one non-respiratory measurement made on the subject, and wherein said at least one non-respiratory measurement made on the subject is utilized to provide said indication of the arterial carbon dioxide partial pressure of the subject.

18. Apparatus for computerized breath analysis according to claim 17 and wherein said at least one non-respiratory measurement made on the subject provides information about the condition of the blood circulation such that said information is used to correlate transfer of arterial carbon dioxide from the blood to the exhaled breath of the subject.

19. Apparatus for computerized breath analysis according to claim 17 and wherein said at least one non-respiratory measurement made on the subject provides information about the content of the blood such that said information is used to correlate transfer of arterial carbon dioxide from the blood to the exhaled breath of the subject.

20. Apparatus for computerized breath analysis according to claim 17 and wherein said at least one non-respiratory measurement made on the subject comprises at least one of:

an ECG measurement;

a pulse rate measurement;

a pulse oximetric measurement of arterial oxygen saturation level;

a cardiac output measurement; and

a body temperature measurement.

21. Apparatus for computerized breath analysis according to claim 1 and wherein said apparatus utilizes output of said breath analyzer to provide said indication of said discrepancy.

22. Apparatus for computerized breath analysis comprising:

a breath receiver adapted to be placed in fluid communication with a subject;

a gas analyzer coupled to said breath receiver for measuring the carbon dioxide partial pressure of said breath;

a capnographic interpreter unit coupled to said breath analyzer which analyzes carbon dioxide waveform shape of at least one breath of the subject for its carbon dioxide content and provides at least one waveform output parameter characteristic of said waveform shape;

a respiration diagnosis generator; and

at least one input receiving at least one non-respiratory measurement made on the subject;

wherein said respiration diagnosis generator provides a diagnostic determination of the respiratory state of the subject based on said at least one waveform output parameter and on said at least one non-respiratory measurement.

23. Apparatus for computerized breath analysis according to claim 22 and wherein said at least one non-respiratory measurement made on the subject comprises at least one of:

an ECG measurement;

a pulse rate measurement;

a pulse oximetric measurement of arterial oxygen saturation level;

a cardiac output measurement; and

a body temperature measurement.