Methods and devices for obstructing and aspirating lung tissue segments

• US 6,997,918 B2
• Filed: 03/04/2003
• Issued: 02/14/2006
• Est. Priority Date: 10/27/2000
• Status: Expired due to Term

• Current Assignee: Pulmonx Corp.
• Original Assignee: Pulmonx Pulmonx
• Inventors: Kotmel, Robert, Buch, Wally S., Soltesz, Peter P., Reilly, Michael P., Wondka, Tony
• Primary Examiner(s): Evans, Robin O.
• Assistant Examiner(s): Fastovsky, Leonid M.
• Application Number:
  US10/382,131
• Publication Number:
  US 20040073191A1
• Time in Patent Office: 1,078 Days
• Field of Search: 604/516, 604/509, 604/514, 604/518, 604/48, 604/28, 604/35, 424/423, 128/207.14, 128/207.16, 607/99, 600/114, 600/116, 606/108
• US Class Current: 604/516
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12159 Solid plugs; being solid before insertion
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22068 Centering

Abstract

The present invention provides improved methods, systems, devices and kits for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including coupling an aspiration catheter to an inlet port on the obstruction device and aspirating through the port. Or, providing the port with a valve which allows outflow of gas from the isolated lung tissue segment during expiration of the respiratory cycle but prevents inflow of air during inspiration. In addition, a number of other methods may be used. The obstructive device may remain as an implant, to maintain isolation and optionally allow subsequent aspiration, or the device may be removed at any time.

Claims

1. A method for lung volume reduction, said method comprising:

deploying an obstructive device in a lung passageway to a lung tissue segment;

passing an access tube through the obstructive device;

aspirating the segment through the access tube through the deployed obstructive device to at least partially collapse the lung segment, wherein the obstructive device is left in place as an implant after aspiration is complete, wherein the aspirating comprises coupling an aspiration catheter to the access tube and aspirating gas through the catheter from the lung segment.

2. A method as in claim 1, wherein the obstructive device comprises a self-sealing septum and passing comprises piercing the access tube through the septum.

3. A method as in claim 2, wherein the septum comprises a solid membrane or a pre-cut membrane.

4. A method as in claim 1, wherein aspirating comprises:

advancing an aspiration catheter into the lung passageway toward the obstructive device, wherein the aspiration catheter has an occlusion balloon near its distal end;

inflating the occlusion balloon to substantially occlude the lung passageway proximal to the obstructive device; and

aspirating gas through the access tube and the catheter.

5. A method as in claim 1, wherein the obstructive device comprises a structural support and deploying comprises expanding the structural support so that it anchors in the passageway.

6. A method as in claim 5, wherein the structural support comprises a self-expanding support and expanding comprises releasing the self-expanding support from constraint so that it expands and thereby anchors in the passageway.

7. A method as in claim 6, wherein deploying further comprises inflating a balloon which expands the structural support.

8. A method as in claim 1, further comprising positioning an access catheter in the lung passageway prior to deployment of the obstructive device, said access catheter having a proximal end, a distal end, and at least one lumen extending therethrough.

9. A method as in claim 8, wherein the access catheter has an occlusion balloon near its distal end and aspirating comprises:

inflating the occlusion balloon to substantially occlude the lung passageway proximal to the obstructive device; and

aspirating gas through the access tube and the catheter.

10. A method as in claim 9, wherein the access catheter provides optical imaging.

11. A method as in claim 9, wherein the access catheter is steerable.

12. A method as in claim 9, wherein the access catheter is positioned with the use of a guidewire.

13. A method as in claim 12, wherein the guidewire provides imaging capabilities.

14. A method as in claim 1, further comprising introducing a gas or liquid to the segment prior to aspiration.

15. A method as in claim 14, wherein the gas comprises 100% oxygen, a Helium-Oxygen mixture or a low molecular weight gas.

16. A method as in claim 14, wherein the liquid comprises perfluorocarbon or a drug.