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Composite arrays utilizing microspheres

  • US 6,998,274 B2
  • Filed: 07/12/2002
  • Issued: 02/14/2006
  • Est. Priority Date: 12/28/1998
  • Status: Expired due to Term
First Claim
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1. A method of making a composite array composition comprising:

  • a) providing a substrate with a surface comprising a plurality of assay locations, each assay location comprising an array location, said array location comprising a plurality of discrete sites; and

    b) providing a population of microspheres comprising at least a first and a second subpopulation, wherein said first subpopulation comprises a first bioactive agent and wherein said second subpopulation comprises a second bioactive agent;

    wherein said microspheres are randomly distributed in said discrete sites in said array location; and

    c) contacting said randomly distributed microspheres with a plurality of different decoder binding ligands, whereby the location of said bioactive agents is determined.

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